Impact of a Standardized Beta-Lactam Allergy Questionnaire on Aztreonam Use

Journal of Pharmacy Practice
Kacie E ClarkAmeen Pirasteh

Abstract

This quasi-experimental study compared the aztreonam utilization in patients with self-reported beta-lactam allergies admitted to an inpatient service between two study periods (pre- and post-implementation). Post-implementation followed the initiation of a standardized beta-lactam allergy questionnaire, a student pharmacist-driven performance improvement project for beta-lactam allergy documentation. Interviews clarified the allergy, reaction history, and any previous tolerance of beta-lactams. If receiving aztreonam at the time of the questionnaire, recommendations were made for changes in therapy if deemed appropriate by the pharmacist. A total of 95 patients were included in the pre-implementation group versus 65 patients in the post-implementation group. Baseline characteristics were similar. The average number of aztreonam doses per 1000 patient-days in the post-implementation group was decreased (21.23 vs 9.05, P = .003). The average number of days of therapy per 1000 patient-days in the post-implementation group was decreased (8.79-4.24, P = .016). An increase in the number of aztreonam de-escalations was observed post-implementation (P = .003). A total of 122 questionnaires were completed with 114 allergy documentation...Continue Reading

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Citations

Jun 30, 2019·Pharmacy : Journal of Pharmacy, Education and Practice·Elizabeth W CovingtonC Whitney White
May 27, 2021·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Shaina KwiatkowskiNisha Patel
Aug 9, 2019·International Archives of Allergy and Immunology·Elissa AbramsMoshe Ben-Shoshan
Dec 11, 2021·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Courtney L GaberinoSheran S Mahatme

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