Impact of a statewide childhood vaccine program in controlling hepatitis A virus infections in Alaska

Vaccine
Rosalyn J SingletonBrian J McMahon

Abstract

Historically, Alaska experienced cyclic hepatitis A virus (HAV) epidemics, and the HAV rate among Alaska Native people was significantly higher than among other racial/ethnic groups. We evaluated the impact of universal childhood vaccination, initiated in 1996, on HAV epidemiology in Alaska by analyzing HAV cases reported to the State of Alaska. HAV incidence in all age groups declined 98.6% from 60.0/100,000 in 1972-1995 to 0.9/100,000 in 2002-2007. The largest decrease (99.9%) was in Alaska Native people, whose incidence (0.3) in 2002-2007 was lower than the overall U.S. 2007 rate (1.0). Among age groups, the decrease (99.8%) among children aged 0-14 years was the largest. Routine childhood vaccination has nearly eliminated HAV infection in Alaska.

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Citations

Feb 27, 2016·MMWR Supplements·Trudy V MurphyJohn D Ward
Mar 1, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Umid M SharapovBrian J McMahon
Dec 4, 2012·The Journal of Infectious Diseases·Gregory A RaczniakBrian J McMahon
Jul 31, 2016·Public Health·M BruceA Koch
Oct 28, 2016·Human Vaccines & Immunotherapeutics·Anke L StuurmanDaniel Shouval
Apr 18, 2018·Journal of Medical Virology·Emily MositesBrian McMahon
Sep 25, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ian D PlumbBrian J McMahon
Dec 17, 2020·Human Vaccines & Immunotherapeutics·Christian HerzogPierre Van Damme
Apr 3, 2021·American Journal of Preventive Medicine·Nicole L HairCarly J Urban

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