Impact of A1C screening criterion on the diagnosis of pre-diabetes among U.S. adults.

Diabetes Care
Devin M MannPaul Muntner

Abstract

New clinical practice recommendations include A1C as an alternative to fasting glucose as a diagnostic test for identifying pre-diabetes. The impact of these new recommendations on the diagnosis of pre-diabetes is unknown. Data from the National Health and Nutrition Examination Survey 1999-2006 (n = 7,029) were analyzed to determine the percentage and number of U.S. adults without diabetes classified as having pre-diabetes by the elevated A1C (5.7-6.4%) and by the impaired fasting glucose (IFG) (fasting glucose 100-125 mg/dl) criterion separately. Test characteristics (sensitivity, specificity, and positive and negative predictive values) using IFG as the reference standard were calculated. The prevalence of pre-diabetes among U.S. adults was 12.6% by the A1C criterion and 28.2% by the fasting glucose criterion. Only 7.7% of U.S. adults, reflecting 61 and 27% of those with pre-diabetes by A1C and fasting glucose, respectively, had pre-diabetes according to both definitions. A1C used alone would reclassify 37.6 million Americans with IFG to not having pre-diabetes and 8.9 million without IFG to having pre-diabetes (46.5 million reclassified). Using IFG as the reference standard, pre-diabetes by the A1C criterion has 27% sensitiv...Continue Reading

References

May 10, 2001·JAMA : the Journal of the American Medical Association·F de VegtR J Heine
Feb 8, 2002·The New England Journal of Medicine·William C KnowlerUNKNOWN Diabetes Prevention Program Research Group
Jun 28, 2002·Lancet·Jean-Louis ChiassonUNKNOWN STOP-NIDDM Trail Research Group
Dec 25, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Josef CoreshAndrew S Levey
Jun 29, 2004·Diabetes Care·David E GoldsteinDavid B Sacks
Mar 1, 2007·Diabetes Care·David M NathanUNKNOWN American Diabetes Association
Jan 22, 2008·Journal of the American College of Cardiology·Yamini S LevitzkyCaroline S Fox
Mar 1, 2008·Diabetes Care·UNKNOWN American Diabetes Association
Oct 8, 2009·Diabetes Care·Mary K RheeLawrence S Phillips
Nov 6, 2009·Journal of General Internal Medicine·K M Venkat Narayan, David F Williamson
Jan 29, 2010·Diabetes Care·UNKNOWN American Diabetes Association
Mar 5, 2010·The New England Journal of Medicine·Elizabeth SelvinFrederick L Brancati

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Citations

Aug 10, 2012·The New England Journal of Medicine·Silvio E Inzucchi
Aug 23, 2011·Diabetes Technology & Therapeutics·Roma Y GianchandaniRodica Pop-Busui
Dec 4, 2012·Clinical and Experimental Pharmacology & Physiology·Ting-Ting DuXue-Feng Yu
Feb 4, 2014·Current Diabetes Reports·Emma M Eggleston, Elissa R Weitzman
Mar 15, 2014·Acta Diabetologica·Christian S GöblAlexandra Kautzky-Willer
Jul 16, 2011·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Pascal BovetIsabelle Hagon-Traub
May 4, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·D BenaigesJ A Flores-Le Roux
Sep 16, 2011·Current Medical Research and Opinion·Niki KatsikiVivian A Fonseca
Feb 22, 2014·The American Journal of the Medical Sciences·Aidar R Gosmanov, Jim Wan
Aug 2, 2014·European Journal of Heart Failure·Israel GotsmanAndre Keren
Feb 18, 2012·American Journal of Clinical Pathology·Tomoyuki Kawada
Feb 2, 2011·The Medical Clinics of North America·Stephen Colagiuri
May 11, 2013·Diabetic Medicine : a Journal of the British Diabetic Association·C M BuckleyP M Kearney
Jun 11, 2015·Drugs·Ulrike HostalekSteven Hildemann
Jun 13, 2012·Diabetes Care·María José PicónFrancisco J Tinahones
Jul 2, 2016·Diabetes Research and Clinical Practice·Chul-Hee KimJoong-Yeol Park
Sep 28, 2014·Journal of Diabetes Science and Technology·Jeff CobbEle Ferrannini

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