Impact of ABO blood type on outcomes in patients with primary nonmuscle invasive bladder cancer

The Journal of Urology
Tobias KlatteShahrokh F Shariat

Abstract

ABO blood type is an established prognostic factor for several malignancies but its role in bladder urothelial carcinoma is largely unknown. We determined whether ABO blood type is associated with the outcome of transurethral resection of nonmuscle invasive bladder urothelial carcinoma. We retrospectively studied ABO blood types in 931 patients with primary nonmuscle invasive bladder urothelial carcinoma treated with transurethral bladder resection with or without intravesical instillation therapy. Disease recurrence and progression were analyzed with univariable and multivariable competing risks regression models. Median followup was 67 months. Discrimination was evaluated by the concordance index. The ABO blood type was O, A, B and AB in 414 (44.5%), 360 (38.7%), 103 (11.1%) and 54 patients (5.8%), respectively. ABO blood type was significantly associated with outcome on univariable and multivariable analysis. Overall, patients with blood type O had worse recurrence and progression rates than those with A (p = 0.015 and 0.031) or B (p = 0.004 and 0.075, respectively). The concordance index of multivariable base models increased after including ABO blood type. In patients with nonmuscle invasive bladder urothelial carcinoma th...Continue Reading

References

Jan 1, 1990·European Urology·B LlopisJ F Jiménez-Cruz
Oct 1, 1987·The Journal of Urology·E Orihuela, R S Shahon
Mar 20, 1998·International Journal of Cancer. Journal International Du Cancer·I OrlowC Cordón-Cardó
Aug 1, 2002·Proceedings of the National Academy of Sciences of the United States of America·Senitiroh Hakomori
Jan 30, 2004·International Journal of Cancer. Journal International Du Cancer·Shan GaoErik Dabelsteen
May 10, 2005·Laboratory Investigation; a Journal of Technical Methods and Pathology·Yoshitomo ChiharaYoshihiko Hirao
Jul 13, 2005·Transfusion Medicine Reviews·Mark H Yazer
Jan 22, 2013·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Jul 6, 2013·European Urology·Marko BabjukUNKNOWN European Association of Urology

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Citations

Mar 29, 2014·International Urology and Nephrology·Evren SüerYaşar Bedük
Oct 14, 2016·Chinese Journal of Cancer·Ting JinWei-Han Hu
Aug 19, 2015·Korean journal of urology·M Hammad Ather, Syed M Nazim
Mar 17, 2020·Internal Medicine·Yoshinori TanakaUNKNOWN Ehime Pancreato-Cholangiology (EPOCH) Study Group
Jul 24, 2020·PloS One·Monica S Y NgAndrew J Mallett

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