Impact of Acellular Dermal Matrix on Postsurgical Wound Fluid Biomarkers in Prosthetic Breast Reconstruction

Annals of Plastic Surgery
Henry C HsiaJean E Schwarzbauer

Abstract

Despite the widespread practice of using biologic scaffolds for soft tissue reinforcement over prosthetic implants, the impact of acellular dermal matrix (ADM) on surgical wound fluid biomarkers over the initial postoperative period after prosthetic breast reconstruction remains poorly understood. Patients undergoing prosthetic breast reconstruction surgery where ADM was likely to be used were consented to have fluid samples collected from surgical drains after surgery. Sample collections occurred at an "Early" time point at 24 to 48 hours after surgery and then a "Late" time point approximately 1 to 2 weeks after surgery. All procedures were performed by a single surgeon. Acellular dermal matrix was placed when prosthetic coverage with autologous tissue could not be achieved. Laboratory analyses were performed in blinded fashion without the knowledge of whether the samples came from the ADM "Present" or "Not Present" group. Twenty-one patients were in the ADM Present group and 18 patients were in the Not Present group. Both groups showed similar demographics based on age and body mass index. Analyses for cell concentration, protein concentration, extracellular matrix protein levels, cell proliferation activity, and matrix meta...Continue Reading

References

Dec 15, 2000·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·E A Baker, D J Leaper
May 4, 2002·Nature Reviews. Molecular Cell Biology·James J TomasekRobert A Brown
Jun 4, 2005·The Journal of Biological Chemistry·Henry C Hsia, Jean E Schwarzbauer
Aug 24, 2006·The Journal of Surgical Research·Henry C Hsia, Jean E Schwarzbauer
Feb 6, 2007·Clinics in Dermatology·Jie LiRobert Kirsner
Mar 27, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Gregory S Schultz, Annette Wysocki
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Nov 1, 2012·Plastic and Reconstructive Surgery·Ron Israeli
Mar 19, 2015·Advances in Wound Care·Meilang Xue, Christopher J Jackson

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Citations

Oct 9, 2019·Plastic and Reconstructive Surgery. Global Open·Gabriel M KleinDuc T Bui

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