Impact of achieved systolic blood pressure on renal function in hypertensive patients

European Heart Journal. Quality of Care & Clinical Outcomes
Peter M OkinRichard B Devereux

Abstract

There is strong evidence for the association of high blood pressure (BP) with depressed renal function. Although high BP at baseline is associated with greater progression of chronic kidney disease (CKD), randomized trials in CKD patients have found no significant relationship between more intensive BP control and glomerular filtration rate (GFR) decline. However, the relationship of GFR and change in GFR over time to lower achieved systolic BP (SBP) in hypertensive patients undergoing treatment is unclear. Baseline estimated GFR (eGFR) and change in eGFR during follow-up were examined in relation to average on-treatment SBP in 8778 hypertensive patients with ECG left ventricular hypertrophy (LVH) randomly assigned to losartan- or atenolol-based treatment. GFR was estimated using the Modification of Diet in Renal Disease study equation. Patients with average on-treatment SBP ≤130 mmHg (lowest quintile at last measurement) and average SBP between 131 and 141 mmHg were compared with patients with average SBP ≥142 mmHg (median SBP at last measurement). Patients with an average on-treatment SBP ≤130 mmHg had significantly lower baseline eGFR than those with average SBP between 131 and 141 or average SBP ≥142 mmHg (65.5 ± 14.3 vs. 6...Continue Reading

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Citations

Oct 1, 2016·European Heart Journal. Quality of Care & Clinical Outcomes·William E MoodyJonathan N Townend

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