Impact of acquisition and analysis strategies on cortical depth-dependent fMRI

NeuroImage
Sriranga KashyapKâmil Uludağ

Abstract

Functional MRI at ultra-high magnetic fields (≥ 7T) provides the opportunity to probe columnar and laminar processing in the human brain in vivo at sub-millimeter spatial scales. However, fMRI data only indirectly reflects the neuronal laminar profile due to a bias to ascending and pial veins inherent in gradient- and spin-echo BOLD fMRI. In addition, accurate delineation of the cortical depths is difficult, due to the relatively large voxel sizes and lack of sufficient tissue contrast in the functional images. In conventional depth-dependent fMRI studies, anatomical and functional data are acquired with different image read-out modules, the fMRI data are distortion-corrected and vascular biases are accounted for by subtracting the depth-dependent activation profiles of different stimulus conditions. In this study, using high-resolution gradient-echo fMRI data (0.7 mm isotropic) of the human visual cortex, we propose instead, that depth-dependent functional information is best preserved if data analysis is performed in the original functional data space. To achieve this, we acquired anatomical images with high tissue contrast and similar distortion to the functional images using multiple inversion-recovery time EPI, thereby eli...Continue Reading

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Citations

Mar 1, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ola NorbeckStefan Skare
Sep 17, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Rüdiger Stirnberg, Tony Stöcker
Aug 2, 2018·Frontiers in Neuroanatomy·Matthew E LarkumLars Muckli
Nov 22, 2018·Scientific Reports·Sriranga KashyapKâmil Uludağ
Nov 11, 2020·ELife·Elisa ZamboniZoe Kourtzi
Nov 17, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Kimberly B Weldon, Cheryl A Olman
Feb 8, 2021·Journal of Neuroscience Methods·Irati MarkuerkiagaDavid G Norris
Oct 23, 2020·Progress in Neurobiology·Emily S FinnPeter A Bandettini
Mar 21, 2021·Progress in Neurobiology·Alessio FracassoNatalia Petridou
Mar 27, 2021·Frontiers in Neuroscience·Rodolfo Abreu, João Valente Duarte
Mar 31, 2021·NeuroImage·Rosa M Sanchez PanchueloSusan T Francis
Apr 15, 2021·STAR Protocols·Ke JiaZoe Kourtzi
Mar 30, 2020·Current Biology : CB·Andrew S PersichettiAlex Martin
Apr 27, 2021·The European Journal of Neuroscience·Maxwell R BennettWilliam G Gibson
May 16, 2021·NeuroImage·Laurentius Renzo HuberOmer Faruk Gulban
Sep 4, 2021·NeuroImage·Luisa RaimondoWietske van der Zwaag
Oct 12, 2021·Frontiers in Neuroscience·Pei HuangJohan D Carlin
Sep 24, 2019·NeuroImage·Martin Havlicek, Kâmil Uludağ

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