Impact of activating killer immunoglobulin-like receptor genotype on outcome of unrelated donor-hematopoietic cell transplantation

Transplantation Proceedings
Sebastian GiebelJerzy Holowiecki

Abstract

In a previous study we demonstrated that incompatibility regarding ligands for inhibitory killer immunoglobulin-like receptors (KIRs) is associated with a survival advantage following unrelated donor-hematopoietic cell transplantation (URD-HCT). The goal of the present analysis was to evaluate whether genotype of activating KIRs of the donor may have an impact on the outcome of URD-HCT. Twenty-five URD-HCT recipients with hematological malignancies, mean age 27 years (range, 14-43 years), were included in the analysis. The conditioning regimen was myeloablative and based on chemotherapy alone (n = 20) or total body irradiation (n = 5). Graft-versus-host disease (GVHD) prophylaxis consisted of cyclosporine, methotrexate, and pretransplant antithymocyte globulin. Patients were grouped according to their donors' activating KIR genotype including two loci: KIR2DS1 and KIR2DS2. The presence of KIR2DS1 in the donor (n = 16/25) was not demonstrated to influence outcome. In contrast, the presence of KIR2DS2 (n = 13/25 donors) was associated with decreased probability of overall survival (0% vs 92%, P = .04) and disease-free survival (0% vs 92%, P = .046). The reason for failures in the KIR2DS2-positive group was chronic GVHD (n = 4), a...Continue Reading

References

Mar 31, 2000·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·H G Klingemann
Feb 19, 2005·International Journal of Hematology·Loredana RuggeriAndrea Velardi
Jun 28, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Xiao-Dong MoXiao-Jun Huang

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Citations

Nov 19, 2013·Cellular & Molecular Immunology·Diana N EissensIrma Joosten
Nov 30, 2007·Leukemia·S Verheyden, C Demanet
Feb 2, 2010·Bone Marrow Transplantation·S GiebelJ Holowiecki
May 16, 2007·Médecine sciences : M/S·Alexandre IannelloAli Ahmad
Mar 27, 2013·Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih·Bao-zhi FangSu-ning Chen
Nov 20, 2008·European Journal of Immunology·Maelig MorvanChristelle Retière
Apr 21, 2007·Tissue Antigens·K GagneUNKNOWN ARS 2000 FRM and FGM group
Oct 5, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D N EissensI Joosten
Aug 5, 2011·British Journal of Haematology·Wing Leung
Aug 29, 2006·Seminars in Cancer Biology·William H D Hallett, William J Murphy
Dec 27, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Toshio YabeUNKNOWN Japan Marrow Donor Program
Oct 28, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Johannes ClausenDavid Nachbaur
Apr 20, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Vanderson RochaUNKNOWN Eurocord, Cord Blood Committee Cellular Therapy Immunobiology Working Party of the European Group for Blood and Marrow Trans
May 26, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Veronika BachanovaSarah A Cooley
Sep 18, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rafijul BariWing Leung
Sep 18, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Richard J O'Reilly
Mar 18, 2011·Journal of Innate Immunity·Stéphanie NguyenVincent Vieillard
Feb 24, 2017·Frontiers in Immunology·Silke Heidenreich, Nicolaus Kröger
Jan 1, 2011·Revista brasileira de hematologia e hemoterapia·Danilo Santana Alessio FranceschiJeane Eliete Laguila Visentainer

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