Impact of Acute and Chronic Amyloid-β Peptide Exposure on Gut Microbial Commensals in the Mouse

Frontiers in Microbiology
Malena Dos Santos GuilhermeKristina Endres

Abstract

Alzheimer's disease (AD) is the most common form of dementia. Besides its cognitive phenotype, AD leads to crucial changes in gut microbiome composition in model mice and in patients, but the reported data are still highly inconsistent. Therefore, we investigated chronic effects of AD-characteristic neurotoxic amyloid-β (Aβ) peptides as provided by transgenic overexpression (5xFAD mouse model) and acute effects due to oral application of Aβ on gut microbes. Astonishingly, one-time feeding of wild type mice with Aβ42 provoked immediate changes in gut microbiome composition (β diversity) as compared to controls. Such obvious changes were not observed when comparing 5xFAD mice with wild type littermates. However, acute as well as chronic exposure to Aβ significantly affected the abundance of numerous individual operational taxonomic units. This provides first evidence that acute in vivo exposure to Aβ results in a shift in the enteric microbiome. Furthermore, we suggest that chronic exposure to Aβ might trigger an adaptive response of gut microbiota which could thereby result in dysbiosis in model mice but also in human patients.

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Citations

Jul 25, 2020·The Journal of Physiology·Karl-Herbert SchäferManuela Gries
Feb 14, 2021·Biomolecules·Maria Jose Carranza-NavalAngel Del Marco
May 1, 2021·Microorganisms·Malena Dos Santos GuilhermeKristina Endres
Jun 15, 2021·Frontiers in Aging Neuroscience·Shaochang WuZongxin Ling
Nov 4, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sik Yu So, Tor C Savidge

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Datasets Mentioned

BETA
PRJNA627235

Methods Mentioned

BETA
biopsies
transgenic
Assay
Illumina sequencing
amplicon sequencing

Software Mentioned

QIIME2
scikit
GraphPad Prism
BBMerge
phyloseq R
QIIME
CAP
MAFFT
DESeq2
learn

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