Impact of acute exposure to tobacco smoke on gelatinases in the bronchoalveolar space

The European Respiratory Journal
P GladerA Linden

Abstract

Clinical studies have indicated increased gelatinase activity in the airways of patients suffering from chronic obstructive pulmonary disease caused by tobacco smoke. The present study aimed to determine whether acute exposure to tobacco smoke per se causes a substantial and lasting impact on gelatinases and their inhibitors in the peripheral airways of atopic and nonatopic human subjects. Bronchoscopy with bronchoalveolar lavage (BAL) was performed on occasional smokers with and without atopy before and after smoking 10 cigarettes over a 48-h period. Samples from a group of never-smokers not exposed to tobacco smoke served as controls. Gelatinase identity and activity were measured using zymography, and gelatinase activity assay and concentrations of matrix metalloproteinase (MMP)-2, MMP-9, tissue inhibitor of MMP (TIMP)-1 and TIMP-2 were measured using ELISA. The results revealed no pronounced changes in identity, net activity or concentration of the gelatinases or changes in concentrations of TIMP-1 and TIMP-2 in BAL fluid before and after acute exposure to tobacco smoke. In conclusion, the present experimental study indicates that acute exposure to tobacco smoke does not cause any substantial impact on gelatinases or their ...Continue Reading

Citations

Oct 8, 2014·American Journal of Respiratory and Critical Care Medicine·Karlhans F CheAnders Lindén
Apr 27, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Gerdt C RiiseAnders Lindén
Nov 3, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Anders AnderssonAnders Lindén
May 22, 2018·Clinical Science·Karlhans Fru CheAnders Lindén

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