Impact of acute inflammation on the extinction of aversive gut memories.

Brain, Behavior, and Immunity
Sven BensonHarald Engler

Abstract

Impaired extinction of pain-related fear memories can lead to persistent or resurging fear of pain, contributing to the development and maintenance of chronic pain conditions. The mechanisms underlying maladaptive pain-related learning and memory processes remain incompletely understood, particularly in the context of interoceptive, visceral pain. Inflammation is known to interfere with learning and memory, but its effects on the extinction of pain-related fear memories have never been tested. In a randomized, double-blind, placebo-controlled study, we assessed the impact of experimental acute inflammation on the extinction and reinstatement of conditioned visceral pain-related fear. Forty healthy male volunteers underwent differential fear conditioning with visceral pain as clinically relevant unconditioned stimulus (US). Participants then received an intravenous injection of either 0.8 ng/kg lipopolysaccharide (LPS) as inflammatory stimulus or physiological saline as placebo, and extinction training was conducted at the peak of the inflammatory response. Extinction recall and reinstatement test were performed after overnight consolidation. Results showed that visceral pain represents an effective US, eliciting pronounced cond...Continue Reading

References

Jun 26, 1999·Lancet·F Cervero, J M Laird
Oct 7, 2004·Learning & Memory·Mark E Bouton
Mar 30, 2011·Proceedings of the National Academy of Sciences of the United States of America·Dominique J-F de QuervainFrank H Wilhelm
Apr 28, 2011·Brain, Behavior, and Immunity·Harald EnglerManfred Schedlowski
Jul 23, 2011·Neuroscience and Biobehavioral Reviews·Paul J KennedyJohn F Cryan
Dec 2, 2011·Annual Review of Psychology·Mohammed R Milad, Gregory J Quirk
Dec 14, 2011·PloS One·Jan-Sebastian GrigoleitManfred Schedlowski
Jan 10, 2012·Current Opinion in Psychiatry·Herta Flor
Mar 20, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Rebecca M Lovell, Alexander C Ford
Nov 20, 2012·Biological Psychiatry·Bronwyn M Graham, Mohammed R Milad
Mar 30, 2013·Annual Review of Clinical Psychology·Bram VervlietDirk Hermans
Sep 13, 2013·European Journal of Pain : EJP·T E LacourtS Elsenbruch
Feb 5, 2014·Brain, Behavior, and Immunity·Manfred SchedlowskiJan-Sebastian Grigoleit
Feb 6, 2014·Psychoneuroendocrinology·Christian J MerzOliver T Wolf
May 28, 2014·Behaviour Research and Therapy·Michelle G CraskeBram Vervliet
Aug 17, 2014·Learning & Memory·Jan HaakerTina B Lonsdorf
Aug 26, 2014·Neurobiology of Learning and Memory·Elissa J Donzis, Natalie C Tronson
Jan 6, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A IcenhourS Elsenbruch
Sep 12, 2015·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Marlies den HollanderJohan W S Vlaeyen
Nov 2, 2015·Brain, Behavior, and Immunity·María M QuiñonesJames T Porter
Dec 8, 2015·Frontiers in Behavioral Neuroscience·Franziska LabrenzSigrid Elsenbruch
Jan 7, 2016·Frontiers in Behavioral Neuroscience·Sigrid Elsenbruch, Oliver T Wolf
Aug 9, 2016·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Manuel KuhnTina B Lonsdorf
Oct 26, 2016·The Journal of Pain : Official Journal of the American Pain Society·Ann MeuldersJohan W S Vlaeyen
Nov 25, 2016·Nature Reviews. Neuroscience·Dominique de QuervainBenno Roozendaal
Sep 28, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Christian Josef MerzAndrea Hermann
Dec 31, 2018·Neuroscience and Biobehavioral Reviews·Shira Meir DrexlerOliver T Wolf
Mar 25, 2019·The Journal of Pain : Official Journal of the American Pain Society·Katharina SchmidtUlrike Bingel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.