Abstract
Adenoviremia adversely affects prognosis in the post-hematopoietic stem cell transplant setting. We sought to determine retrospectively the cutoff load of adenovirus in the stool as a predictor of adenoviremia, in children who underwent an allogeneic hematopoietic stem cell transplant. The prevalence of sapovirus, norovirus and astrovirus in the stool was also studied. The study cohort consisted of 117 patients, of which 71 (60%) had diarrhea. Adenovirus was detected in the stool in 39 of 71 (55%) patients. Age ≤10 years (P = 0.05; odds ratio: 2.57; 95% confidence interval: 0.98-6.75) and male sex (P = 0.04; odds ratio: 2.67; 95% confidence interval: 1.02-6.99) increased risk for detection of adenovirus in stool on univariate analysis. Coinfections with enteric pathogens were infrequent. Viral load >10 copies/g stool predicted adenoviremia with a sensitivity and specificity of 82%. Sapovirus, norovirus and astrovirus were detected in 3, 4 and 1 patient, respectively. Quantitative detection of adenovirus in stool may have implications for preemptive therapy. Testing for other enteric viruses may have implications for infection control.
References
Dec 16, 1998·Bone Marrow Transplantation·M KondoT Matsuyama
Feb 16, 2000·Bone Marrow Transplantation·S ChakrabartiD W Milligan
Aug 13, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marco W SchilhamMaarten J van Tol
Aug 15, 2002·Blood·Suparno ChakrabartiDonald W Milligan
Oct 9, 2003·Journal of Clinical Microbiology·Z GuR T Hayden
May 24, 2005·Bone Marrow Transplantation·M J D van TolJ M Vossen
Feb 24, 2007·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Aloys C M KroesMaarten J D van Tol
Sep 21, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Veronique ErardMichael Boeckh
Feb 12, 2010·Leukemia·T LionS Matthes-Martin
Apr 13, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·H JeulinV Venard
Apr 21, 2011·Pediatric Transplantation·M A SaifR F Wynn
Oct 4, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Diana F FlorescuCharles van der Horst
Oct 21, 2011·Journal of Medical Virology·Olga MoserArne Simon
Nov 19, 2011·PloS One·Werner WunderliCaroline Tapparel
Jan 28, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Theresa WatsonRoberta L DeBiasi
Mar 7, 2012·Antimicrobial Agents and Chemotherapy·Wendy PainterGeorge Painter
Jul 17, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Joseph Delano F RoblesGodfrey Chi Fung Chan
Jun 13, 2013·The Journal of Infectious Diseases·Preeti ChhabraJan Vinjé
Jun 21, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Ulrike GerdemannAnn M Leen
Nov 26, 2013·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Martin MynarekBritta Maecker-Kolhoff
Citations
May 21, 2016·Journal of Medical Virology·Hugo César Pereira SantosMenira Souza
Apr 18, 2018·Reviews in Medical Virology·Prashant HiwarkarThomas Lion
Jun 10, 2016·Journal of Clinical Microbiology·N Esther Babady
Sep 20, 2018·Journal of Medical Virology·Thayara Morais PortalYvone Benchimol Gabbay
Aug 15, 2019·FEBS Letters·Thomas Lion
Sep 25, 2019·Journal of the Pediatric Infectious Diseases Society·Jennifer E SchusterJanet A Englund
Nov 28, 2017·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Brandon M TriplettWing Leung
May 1, 2019·Pediatric Hematology and Oncology·Salah AliTal Schechter
Oct 30, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Ana Milena BravoEduardo López-Medina
Aug 25, 2020·The Science of the Total Environment·David L JonesKata Farkas