Impact of adjuvant systemic chemotherapy on postoperative survival in patients with high-risk urothelial cancer

International Journal of Urology : Official Journal of the Japanese Urological Association
Shin SuzukiTomohiko Koyanagi

Abstract

The objective of this study was to retrospectively investigate the effectiveness of adjuvant combination chemotherapy for locally advanced urothelial cancer. Between 1987 and 1998, 56 patients with locally advanced bladder (n = 27) or upper urinary tract (n = 29) cancer (pathological stage T3, T4 or N1, N2 and M0) were treated by radical cystectomy or radical nephroureterectomy and regional lymphadenectomy. Thirty-one patients had lymph node-positive disease and 25 patients did not. Twenty patients underwent adjuvant chemotherapy and 36 patients were observed after surgery. Cox proportional hazards models were used to determine the impact of numerous clinicopathological findings on survival. A subgroup analysis of patients with lymph node-positive disease was conducted to evaluate disease-free survival and overall survival rates. In this series, the median follow-up period was 39 months (range, 4-163) after surgery. Disease-free and overall survival rates of all 56 patients were 45% and 58%, respectively, at 3 years. Only lymph node status was significantly associated with disease-free and overall survival in the multivariate analyses. In a subgroup analysis of patients with lymph node-positive disease, 16 patients who underwen...Continue Reading

References

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Citations

Apr 1, 2006·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Kwan-Sik BaeSung-Goo Chang
Sep 12, 2014·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·F AudenetP Colin
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Sep 26, 2017·Internal Medicine·Hiroyuki MatsubayashiHiroyuki Ono
Aug 12, 2005·Current Opinion in Urology·Sangtae Park, Maxwell V Meng

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