Abstract
The objective of this study was to retrospectively investigate the effectiveness of adjuvant combination chemotherapy for locally advanced urothelial cancer. Between 1987 and 1998, 56 patients with locally advanced bladder (n = 27) or upper urinary tract (n = 29) cancer (pathological stage T3, T4 or N1, N2 and M0) were treated by radical cystectomy or radical nephroureterectomy and regional lymphadenectomy. Thirty-one patients had lymph node-positive disease and 25 patients did not. Twenty patients underwent adjuvant chemotherapy and 36 patients were observed after surgery. Cox proportional hazards models were used to determine the impact of numerous clinicopathological findings on survival. A subgroup analysis of patients with lymph node-positive disease was conducted to evaluate disease-free survival and overall survival rates. In this series, the median follow-up period was 39 months (range, 4-163) after surgery. Disease-free and overall survival rates of all 56 patients were 45% and 58%, respectively, at 3 years. Only lymph node status was significantly associated with disease-free and overall survival in the multivariate analyses. In a subgroup analysis of patients with lymph node-positive disease, 16 patients who underwen...Continue Reading
References
Aug 1, 1992·The Journal of Urology·M StöckleR Hohenfellner
Mar 1, 1991·The Journal of Urology·D G SkinnerS Groshen
Mar 1, 1985·The Journal of Urology·C N SternbergP C Sogani
Apr 1, 1993·The Journal of Urology·S P LernerB Hopwood
Dec 1, 1996·Urology·M StöckleR Hohenfellner
Oct 14, 1998·Japanese Journal of Clinical Oncology·M KurodaT Kakizoe
Jan 5, 2002·Der Urologe. Ausg. A·H Rübben, T Otto
Citations
Oct 12, 2012·World Journal of Urology·Jan CordierDerya Tilki
Apr 1, 2006·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Kwan-Sik BaeSung-Goo Chang
Sep 12, 2014·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·F AudenetP Colin
Jul 15, 2015·International Journal of Urology : Official Journal of the Japanese Urological Association·Kazutoshi FujitaMotohide Uemura
May 13, 2009·Cancer·Brant A InmanLouis Lacombe
Nov 17, 2005·BJU International·Murugesan ManoharanMark S Soloway
Dec 18, 2008·International Journal of Urology : Official Journal of the Japanese Urological Association·Takahiro OsawaKatsuya Nonomura
Sep 9, 2008·International Journal of Urology : Official Journal of the Japanese Urological Association·Yoshinobu KomaiIwao Fukui
Apr 1, 2014·European Urology·Jeffrey J LeowJoaquim Bellmunt
Mar 5, 2015·Cancer Treatment Reviews·Jeffrey J LeowJoaquim Bellmunt
Apr 4, 2015·Hematology/oncology Clinics of North America·Ilaria LuccaSteven L Chang
Sep 1, 2016·Japanese Journal of Clinical Oncology·Makito MiyakeUNKNOWN Nishinipon Uro-Oncology Collaborative Group
Jan 9, 2016·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Hyung Suk KimJa Hyeon Ku
Nov 4, 2006·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Murugesan ManoharanMark S Soloway
Sep 26, 2017·Internal Medicine·Hiroyuki MatsubayashiHiroyuki Ono
Aug 12, 2005·Current Opinion in Urology·Sangtae Park, Maxwell V Meng
Sep 30, 2016·Oncotarget·Xiao YangZengjun Wang
Oct 10, 2018·World Journal of Urology·Sebastiano NazzaniPierre I Karakiewicz
Apr 25, 2019·International Journal of Surgery·Wan SongHyun Hwan Sung