Impact of Advanced Therapies for Improving Survival to Heart Transplant in Patients with Hypertrophic Cardiomyopathy

The American Journal of Cardiology
Ethan J RowinDavid DeNofrio

Abstract

Heart transplant has become an increasingly important option for patients with end-stage nonobstructive hypertrophic cardiomyopathy (HC). However, clinical details related specifically to the overall HC transplant experience remain sparse. We assessed outcomes of HC heart transplants, from 2002 to 2016, at Tufts Medical Center. Fifty-two nonobstructive severely symptomatic patients underwent evaluation at 47 ± 13 years; 11 (21%) declined or failed to qualify, most commonly because of co-morbidities (n = 7). Of the remaining 41 patients ultimately listed, 6 (15%) died of heart failure awaiting transplant (11%/year), 26 underwent transplant, and 9 remained active on the list. Survival rates on the waiting list depended on ≥1 treatment intervention: inotropic medications (n = 20), ventricular assist devices (n = 7), or implantable defibrillators terminating ventricular tachyarrhythmias (n = 7). Of the 26 transplanted patients, 24 survived for 4.8 ± 3.4 years (up to 12), including 23 who are currently alive. The survival rate 5 years post transplant is 92%. Compared with heart transplants for other cardiomyopathies, patients with HC had similar mortality while wait-listed and post transplant (p = 0.77 and 0.13, respectively). In co...Continue Reading

Citations

Aug 16, 2018·The New England Journal of Medicine·Barry J Maron
Oct 31, 2019·Journal of the American Heart Association·Ethan J RowinBarry J Maron
Apr 17, 2020·Journal of the American Heart Association·Ethan J Rowin, Aadhavi Sridharan
Jul 28, 2020·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Arya AminorroayaPegah Roayaei
Jun 28, 2019·Current Heart Failure Reports·Nosheen RezaAnjali Tiku Owens
Oct 8, 2020·Current Cardiology Reports·James Kogut, Eric D Popjes
Aug 18, 2020·Journal of the American College of Cardiology·Ethan J RowinMartin S Maron
Feb 26, 2021·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Jayakumar SreenivasanPaolo C Colombo
Jan 27, 2019·JACC. Clinical Electrophysiology·Ethan J RowinMartin S Maron
Jun 20, 2020·Journal of the American College of Cardiology·Ethan J RowinMartin S Maron
Oct 9, 2021·Journal of the American Heart Association·Barry J MaronNazzareno Galiè
Dec 31, 2021·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Pietro FranciaCamillo Autore
Dec 30, 2021·Monaldi Archives for Chest Disease = Archivio Monaldi Per Le Malattie Del Torace·Olga VrizGiuseppe Limongelli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Artificial Heart & Ventricular Assist Devices

Total artificial hearts (TAH) and ventricular assist devices (VADs) provide cardiac support for patients with end-stage heart disease and have significantly improved the survival of these patients. Discover the latest research on Artificial Heart and Ventricular Assist Devices here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Related Papers

The American Journal of Cardiology
Elena BiaginiClaudio Rapezzi
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
M Colvin-AdamsB L Kasiske
© 2022 Meta ULC. All rights reserved