Abstract
Heart transplant has become an increasingly important option for patients with end-stage nonobstructive hypertrophic cardiomyopathy (HC). However, clinical details related specifically to the overall HC transplant experience remain sparse. We assessed outcomes of HC heart transplants, from 2002 to 2016, at Tufts Medical Center. Fifty-two nonobstructive severely symptomatic patients underwent evaluation at 47 ± 13 years; 11 (21%) declined or failed to qualify, most commonly because of co-morbidities (n = 7). Of the remaining 41 patients ultimately listed, 6 (15%) died of heart failure awaiting transplant (11%/year), 26 underwent transplant, and 9 remained active on the list. Survival rates on the waiting list depended on ≥1 treatment intervention: inotropic medications (n = 20), ventricular assist devices (n = 7), or implantable defibrillators terminating ventricular tachyarrhythmias (n = 7). Of the 26 transplanted patients, 24 survived for 4.8 ± 3.4 years (up to 12), including 23 who are currently alive. The survival rate 5 years post transplant is 92%. Compared with heart transplants for other cardiomyopathies, patients with HC had similar mortality while wait-listed and post transplant (p = 0.77 and 0.13, respectively). In co...Continue Reading
Citations
Aug 16, 2018·The New England Journal of Medicine·Barry J Maron
May 23, 2019·JAMA Cardiology·Martin S MaronBarry J Maron
Oct 31, 2019·Journal of the American Heart Association·Ethan J RowinBarry J Maron
Apr 17, 2020·Journal of the American Heart Association·Ethan J Rowin, Aadhavi Sridharan
Jul 28, 2020·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Arya AminorroayaPegah Roayaei
Jun 28, 2019·Current Heart Failure Reports·Nosheen RezaAnjali Tiku Owens
Oct 8, 2020·Current Cardiology Reports·James Kogut, Eric D Popjes
Nov 21, 2020·Circulation·Steve R OmmenPaul Sorajja
Nov 25, 2020·Journal of the American College of Cardiology·Steve R OmmenPaul Sorajja
Nov 25, 2020·Journal of the American College of Cardiology·Steve R OmmenPaul Sorajja
Aug 18, 2020·Journal of the American College of Cardiology·Ethan J RowinMartin S Maron
Nov 21, 2020·Circulation·Steve R OmmenPaul Sorajja
Feb 26, 2021·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Jayakumar SreenivasanPaolo C Colombo
Mar 3, 2021·PloS One·Fouad ChouairiTariq Ahmad
May 1, 2021·The Journal of Thoracic and Cardiovascular Surgery·UNKNOWN Writing Committee MembersY Joseph Woo
Jan 27, 2019·JACC. Clinical Electrophysiology·Ethan J RowinMartin S Maron
Jun 26, 2021·The American Journal of Cardiology·Ethan J RowinMartin S Maron
Jun 20, 2020·Journal of the American College of Cardiology·Ethan J RowinMartin S Maron
Oct 9, 2021·Journal of the American Heart Association·Barry J MaronNazzareno Galiè
Dec 31, 2021·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Pietro FranciaCamillo Autore
Dec 30, 2021·Monaldi Archives for Chest Disease = Archivio Monaldi Per Le Malattie Del Torace·Olga VrizGiuseppe Limongelli