Impact of Age and Antibody Type on Progression From Single to Multiple Autoantibodies in Type 1 Diabetes Relatives

The Journal of Clinical Endocrinology and Metabolism
E BosiType 1 Diabetes TrialNet Study Group

Abstract

Islet autoantibodies are markers of type 1 diabetes, and an increase in number of autoantibodies detected during the preclinical phase predicts progression to overt disease. To refine the effect of age in relation to islet antibody type on progression from single to multiple autoantibodies in relatives of people with type 1 diabetes. We examined 994 relatives with normal glucose tolerance who were positive for a single autoantibody, followed prospectively in the TrialNet Pathway to Prevention. Antibodies to glutamic acid decarboxylase (GADA), insulin (IAA), insulinoma-associated antigen 2, and zinc transporter 8 and islet cell antibodies were tested every 6 to 12 months. The primary outcome was confirmed development of multiple autoantibodies. Age was categorized as <8 years, 8 to 11 years, 12 to 17 years, and ≥18 years, and optimal age breakpoints were identified by recursive partitioning analysis. After median follow-up of 2 years, 141 relatives had developed at least one additional autoantibodies. Five-year risk was inversely related to age, but the pattern differed by antibody type: Relatives with GADA showed a gradual decrease in risk over the four age groups, whereas relatives with IAA showed a sharp decrease above age 8 ...Continue Reading

Associated Clinical Trials

References

Oct 1, 2008·Pediatric Diabetes·Jeffrey L MahonUNKNOWN Type 1 Diabetes TrialNet Study Group
Sep 11, 2009·Diabetes Care·Tihamer OrbanUNKNOWN Diabetes Prevention Trial-Type 1 Study Group
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Jun 4, 2016·Journal of Autoimmunity·Andrea K SteckMarian J Rewers

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Citations

Dec 16, 2018·Diabetes Care·Martha L Campbell-ThompsonMichael J Haller
Aug 1, 2018·Diabetes Care·Taylor M TrioloUNKNOWN Type 1 Diabetes TrialNet Study Group
Jan 19, 2019·Reviews in Endocrine & Metabolic Disorders·Christian A Koch, Alessandro Antonelli
Jul 31, 2018·Current Diabetes Reviews·Elin Pettersen Sørgjerd
Aug 10, 2019·Clinical and Experimental Immunology·E Bonifacio, P Achenbach
Jun 7, 2019·Diabetes·Maria J Acevedo-CaladoUNKNOWN Type 1 Diabetes TrialNet Study Group
Sep 20, 2019·Nature Reviews. Endocrinology·Jorma IlonenRiitta Veijola
Aug 7, 2019·Clinical Pediatric Endocrinology : Case Reports and Clinical Investigations : Official Journal of the Japanese Society for Pediatric Endocrinology·Francesco ChiarelliMarina Primavera
Sep 29, 2019·International Journal of Molecular Sciences·Miriam Cabello-OlmoMiguel Barajas
Sep 27, 2019·Current Opinion in Immunology·Samantha Slight-WebbJudith A James
Apr 22, 2021·Endocrine Reviews·Michelle SoCarla J Greenbaum
Aug 8, 2021·Microorganisms·Sonia R IsaacsKi Wook Kim
Oct 7, 2021·Diabetic Medicine : a Journal of the British Diabetic Association·Anna E LongClaire L Williams
Dec 12, 2021·British Medical Bulletin·L A Allen, C M Dayan

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