Impact of age and pre-existing influenza immune responses in humans receiving split inactivated influenza vaccine on the induction of the breadth of antibodies to influenza A strains

PloS One
Ivette A NuñezTed M Ross

Abstract

Most humans have pre-existing immunity to influenza viruses. In this study, volunteers (ages of 18-85 years) were vaccinated with split, inactivated Fluzone™ influenza vaccine in four consecutive influenza seasons from 2013 to 2016 seasons. The impact of repeated vaccination on breadth and durability of antibodies was assessed as a result of vaccine strain changes. Total IgG anti-hemagglutinin (HA) binding antibodies and hemagglutination-inhibition (HAI) activity increased in all age groups against both influenza A HA components in the vaccine post-vaccination (day 21). However, younger subjects maintained seroprotective titers to the vaccine strains, which resulted in higher seroconversion rates in the elderly, since the HAI titers in elderly subjects were more likely to decline prior to the next season. Young subjects had significant HAI activity against historical, as well as contemporary H1 and H3 vaccine strains from the mid-1980s to present. In contrast, elderly subjects had HAI activity to H1 strains from all years, but were more likely to have HAI activity to older strains from 1918-1950s. They also had a more restricted HAI profile against H3 viruses compared to young subjects recognizing H3N2 influenza viruses from th...Continue Reading

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Citations

Jan 27, 2018·Virology Journal·Giuseppe A SauttoTed M Ross
Jul 11, 2019·Human Vaccines & Immunotherapeutics·Michael A CarlockTed M Ross
Sep 19, 2019·Immunity & Ageing : I & a·Stephen N CrookeRichard B Kennedy
Apr 12, 2020·Vaccines·Amanda L Skarlupka, Ted M Ross
Nov 20, 2019·International Journal of Environmental Research and Public Health·Maria GanczakLidia B Brydak
Oct 3, 2019·Expert Review of Vaccines·Hyesun Jang, Ted M Ross
Nov 12, 2019·International Reviews of Immunology·Asim BiswasShanta Dutta
Jun 9, 2020·Frontiers in Immunology·Rodrigo B AbreuTed M Ross
Dec 25, 2019·Cold Spring Harbor Perspectives in Medicine·Jennifer NayakAubree Gordon
Feb 12, 2021·GeroScience·Jennifer ConnorsElias K Haddad
Nov 6, 2020·Vaccines·Rossella CianciGiovanni Gambassi
May 11, 2020·The Journal of Allergy and Clinical Immunology·Claire E GustafsonJörg J Goronzy
Jul 2, 2021·The Journal of Clinical Investigation·Jiwon JungGeorge Georgiou

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Methods Mentioned

BETA
enzyme linked immunosorbent assay

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