Impact of age and socioeconomic status on treatment and survival from aggressive lymphoma: a UK population-based study of diffuse large B-cell lymphoma

Cancer Epidemiology
Alexandra SmithEve Roman

Abstract

To examine the influence of patient's age and socio-economic status on treatment and outcome in diffuse large B-cell lymphoma (DLBCL); an aggressive curable cancer, with an incidence rate that increases markedly with age but varies little with socio-economic status. Set within a representative UK population of around 4 million, data are from an established patient cohort. This report includes all patients (≥ 18 years) newly diagnosed with DLBCL 2004-2012, with follow-up to February 2015. Of the 2137 patients (median age 70.2 years) diagnosed with denovo DLBCL, 1709 (80%) were treated curatively/intensively and 1161(54.3%) died during follow-up. Five-year overall and relative survival (RS) estimates were 46.2% (95% CI 44.0-48.4%) and 54.6% (52.1%-57.0%) respectively for all patients, and 58.5% (56.1-60.9%) and 67.0% (64.3-69.6%) for intensively treated patients. 96.3% of patients <55 years (366/380) and 96.4% of those with the best performance status (543/563) were treated curatively: 5-year RSs being 77.9% (73.1-82%) and 87.1% (82.5-90.6%) respectively. At the other end of the age/fitness spectrum, 33.3% of those ≥ 85 years (66/198) and 41.1% with the worst performance (94/225) were treated curatively: the corresponding 5-year ...Continue Reading

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Citations

Mar 13, 2016·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Han-I WangRussell Patmore
Jan 8, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James N GersonStefan K Barta
Feb 12, 2019·Acta Oncologica·Susanne Oksbjerg DaltonKaae Klaus Andersen
Apr 5, 2018·International Journal of Epidemiology·Alexandra SmithEve Roman
Dec 21, 2018·Journal of Hematology & Oncology·Seok Jin KimWon Seog Kim

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Methods Mentioned

BETA
biopsy

Software Mentioned

R
Stata strel
Stata

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