Impact of age, benign prostatic hyperplasia, and cancer on prostate-specific antigen level

Cancer
Rinaa S PungliaKaren M Kuntz

Abstract

The distribution of prostate-specific antigen (PSA) values for men with or without prostate carcinoma are confounded because of verification bias. Correcting for verification bias, the means and variances of PSA values were estimated in specific clinical scenarios. Existing receiver operating characteristic (ROC) curves, adjusted for the presence of verification bias in a screening population, were used to estimate the mean and variance of PSA values for men with or without prostate carcinoma, stratified by age and the presence or absence of benign prostatic hyperplasia. Men with a suspicious digital rectal exam (nodular) were excluded from analysis. Among men with cancer and the absence of benign prostatic hyperplasia, mean PSA values were 2.05 ng/mL and 2.66 ng/mL for younger (<60 yr) and older (> or =60 yrs) men, respectively. These estimates were 2.56 ng/mL and 3.90 ng/mL in the presence of benign prostatic hyperplasia for younger and older men, respectively. For men without prostate carcinoma, these values were 0.78 ng/mL and 1.23 ng/mL for younger and older men, respectively, among those without benign prostatic hyperplasia, and 0.97 ng/mL and 1.75 ng/mL for younger and older men, respectively, among those with benign pro...Continue Reading

References

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Jun 26, 2003·The New England Journal of Medicine·Ian M ThompsonCharles A Coltman
Jul 25, 2003·The New England Journal of Medicine·Rinaa S PungliaKaren M Kuntz

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Citations

Oct 14, 2009·Human Genetics·Hemang ParikhLaufey Amundadottir
Jun 17, 2006·La Revue du praticien·Arnauld Villers, Nicolas Berthon
Mar 21, 2007·American Journal of Clinical Pathology·Yasser M El-GoharyReda S Saad
Nov 29, 2015·The Urologic Clinics of North America·Michelle L McDonald, J Kellogg Parsons
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Sep 15, 2006·The Nurse Practitioner·Mikel Gray, Terran Sims
Jan 14, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Hao ShenMin Zhu

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