Abstract
The goal of our study was to analyse the impact of age on outcomes in patients who underwent continuous-flow left ventricular assist device (CF-LVAD) placement at our institution. One hundred and twenty-eight patients were implanted with a CF-LVAD between January 2008 and June 2014. Eighty-five patients were implanted with the device as a bridge to transplant (BTT); the remaining (n = 43) were on destination therapy (DT). Each group was divided into patients <65 years old and ≥ 65 years old at device implantation. Patients were followed up for at least 24 months or until transplant or death. Eighty-five patients (66%) received a CF-LVAD as BTT. Patients ≥ 65 years old (n = 8) had a lower preoperative cardiac index and prothrombin time-international normalized ratio (P = 0.009), and a longer stay in the intensive care unit (P = 0.008). Adverse events including infections, re-exploration for bleeding, ischaemic and haemorrhagic stroke, renal failure and right heart failure were comparable in both age groups. Eighty-two percent (n = 63) of the young patients and 75% (n = 6) of the older patients, who were on LVAD as BTT, underwent heart transplant within the first 24 months of LVAD implantation. Overall survival at 3, 6, 12 and 24...Continue Reading
References
Mar 16, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·O H. FrazierK A. Dasse
Dec 1, 2001·The Journal of Thoracic and Cardiovascular Surgery·O H FrazierUNKNOWN HeartMate LVAS Investigators. Left Ventricular Assist System
Apr 17, 2003·The Journal of Thoracic and Cardiovascular Surgery·Vivek RaoYoshifumi Naka
Jun 27, 2006·Transplantation Proceedings·R HuangJ Butler
Feb 13, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Eric S WeissDavid D Yuh
Oct 23, 2008·Interactive Cardiovascular and Thoracic Surgery·Margaret A MurrayTakushi Kohmoto
Apr 1, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Sigrid E SandnerGeorg M Wieselthaler
Jul 13, 2013·Journal of Cardiac Surgery·Spencer D LalondeVivek Rao
Jan 9, 2014·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Anton SabashnikovAndré R Simon
Mar 4, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Ruth Pulikottil-JacobAileen Clarke
May 9, 2014·Texas Heart Institute Journal·Hari R MallidiWilliam E Cohn
May 27, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·James K KirklinJames B Young
Sep 3, 2014·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Anton SabashnikovAron-Frederik Popov
Citations
Dec 23, 2017·BioMed Research International·F GuerraA Capucci
Nov 3, 2017·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·John C O'HoroM Rizwan Sohail
Aug 11, 2019·Journal of the American Geriatrics Society·Ersilia M DeFilippisVeli K Topkara
Jun 14, 2019·Proceedings·David M HarmonShelley A Hall
May 18, 2019·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Evgenij V PotapovFinn Gustafsson
Nov 7, 2018·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Mehmet H AkayIgor D Gregoric
Sep 22, 2020·Archives of Cardiovascular Diseases·Vincent GalandRaphaël P Martins