Impact of age on the diagnostic performances and cut-offs of APRI and FIB-4 for significant fibrosis and cirrhosis in chronic hepatitis B

Oncotarget
Qiang LiLiang Chen

Abstract

Assessing the diagnostic performances of APRI and FIB-4 using age as a categorical marker. 822 chronic hepatitis B (CHB) patients were included. Using METAVIR scoring system as a reference, the performances of APRI and FIB-4 were compared between patients aged≥30 and patients aged<30 years. The APRI AUROC in patients aged<30 years was lower than that in patients aged≥30 years for significant fibrosis (0.61 vs 0.70, p<0.001) and cirrhosis (0.64 vs 0.78, p<0.001). The FIB-4 AUROC in patients aged<30 years was lower than that in patients aged≥30 years for significant fibrosis (0.57 vs 0.65, p<0.001) and cirrhosis (0.63 vs 0.72, p<0.001). Using specificity≥90%, the APRI cut-off in patients aged<30 years was lower than patients aged≥30 years for significant fibrosis (1.0 vs 1.2) and cirrhosis (1.2 vs 1.5). Using sensitivity≥90%, the APRI cut-off in patients aged<30 years was also lower than patients aged≥30 years for significant fibrosis (0.2 vs 0.4) and cirrhosis (0.3 vs 0.5). Using specificity≥90%, the FIB-4 cut-off in patients aged<30 years was lower than that in patients aged≥30 years for significant fibrosis (1.2 vs 2.1) and cirrhosis (1.4 vs 2.6). Using sensitivity≥90%, the FIB-4 cut-off in patients aged<30 years was also lowe...Continue Reading

References

Oct 26, 1978·The New England Journal of Medicine·D F Ransohoff, A R Feinstein
Sep 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A S Lok, C L Lai
Aug 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P Bedossa, T Poynard
Apr 13, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Tony AndreaniRaoul Poupon
Jul 14, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chee-Kin HuiUNKNOWN Hong Kong Liver Fibrosis Study Group
Mar 23, 2012·Journal of Hepatology·UNKNOWN European Association For The Study Of The Liver
Feb 26, 2015·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Fankun MengLei Ding
Apr 26, 2015·Journal of Hepatology·UNKNOWN European Association for Study of Liver, UNKNOWN Asociacion Latinoamericana para el Estudio del Higado
Oct 13, 2015·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Guo YonghaoGuo Wanshen
Nov 14, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Norah A TerraultUNKNOWN American Association for the Study of Liver Diseases
Jan 12, 2017·Alimentary Pharmacology & Therapeutics·V TakyarC Koh

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Methods Mentioned

BETA
biopsy
biopsies
ELISA
PCR

Software Mentioned

SPSS
MedCalc
FibroScan

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