Impact of age on the false negative rate of human papillomavirus DNA test in patients with atypical squamous cells of undetermined significance

Obstetrics & Gynecology Science
Kyu-Hee WonYong-Beom Kim

Abstract

Human papillomavirus (HPV) test was incorporated into the triage of lesser abnormal cervical cytologies: atypical squamous cells of undetermined significance (ASCUS) or low-grade squamous intraepithelial lesion (LSIL). This study aimed to evaluate the impact of age on the efficacy of HPV testing in patients with lesser abnormal cervical cytologies. A total of 439 patients with ASCUS or LSIL were included. The association between age groups and the diagnostic performances of HPV test for high-grade cervical intraepithelial neoplasia (CIN2+) was evaluated. Median age was 44 years (range, 17 to 75 years). ASCUS was more frequently observed in older patients while LSIL was more common in younger patients (P=0.002). CIN2+ was found in 11.3% (32/284) of the ASCUS patients and 12.9% (20/155) of patients with LSIL. Older patients with ASCUS showed lower HPV infection rates (P=0.025), but not LSIL (P=0.114). However, the prevalence of CIN2+ was similar between the age groups with ASCUS or LSIL. In patients with ASCUS, the false negative rate of HPV test for CIN2+ was 6.2%. The false negative rate of the HPV test became higher with increasing of the age after the age of 50 (P=0.034). Our findings suggest that false negative rate of the H...Continue Reading

References

Oct 9, 1998·Obstetrics and Gynecology·J MelnikowL P Howell
Jan 17, 2002·Journal of the National Cancer Institute·Mark E ShermanUNKNOWN Atypical Squamous Cells of Undetermined Significance/Low-Grade Squamous Intraepithelial Lesion Triage Study Group
May 4, 2002·JAMA : the Journal of the American Medical Association·Jane J KimSue J Goldie
Jan 22, 2010·The Lancet Oncology·Guglielmo RoncoUNKNOWN New Technologies for Cervical Cancer screening (NTCC) Working Group
Jan 21, 2012·American Journal of Clinical Pathology·Mark H StolerUNKNOWN ATHENA (Addressing THE Need for Advanced HPV Diagnostics) Study Group
Mar 27, 2013·Journal of Lower Genital Tract Disease·L Stewart MassadUNKNOWN 2012 ASCCP Consensus Guidelines Conference
Apr 4, 2013·Journal of Lower Genital Tract Disease·Hormuzd A KatkiWalter K Kinney
Apr 4, 2013·Journal of Lower Genital Tract Disease·Hormuzd A KatkiWalter K Kinney

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BETA
genotyping
biopsy
hysterectomy
chip
biopsies

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SPSS

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