Impact of age, sex, and comorbidity on cancer therapy and disease progression

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Sumanta Kumar Pal, Arti Hurria

Abstract

A theme of personalized medicine was highlighted at the 2009 Annual Meeting of the American Society of Clinical Oncology. To this end, the current review focuses on the impact of host characteristics (such as age, sex, and comorbidity) as they pertain to cancer biology, treatment efficacy, and tolerance. Increasing age is associated with complex changes in physiology, including alterations in renal and hepatic function, and decreased bone marrow reserve. These may in turn result in alterations in pharmacokinetics and toxicity related to many commonly used anticancer agents. Using tools, such as the geriatric assessment, may help to elucidate the physiologic age of the patient as opposed to the chronologic age. Increasing age is paralleled by an increase in comorbidity, and comorbidity may have independent prognostic implications and substantially impact medical decision making in the patient with cancer. Numerous biologic ties between cancer and comorbidity exist, one example being an association of diabetes with an increased risk of disease recurrence and mortality in the setting of colon cancer. Biologic features can also vary by sex; several biomarkers with either prognostic or predictive value (ie, excisionrepair cross-comp...Continue Reading

References

Jul 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G MilanoF Demard
Aug 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M K FergusonH M Golomb
Nov 1, 1994·Journal of Clinical Epidemiology·M CharlsonJ Gold
Jun 1, 1995·The Australian and New Zealand Journal of Surgery·J E Payne, H J Meyer
Jan 15, 1994·Annals of Internal Medicine·W A Satariano, D R Ragland
Dec 1, 1995·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·T J SmithS M Retchin
Feb 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R SorioS Monfardini
Oct 8, 1997·Cancer·R E Vestal
Apr 29, 1998·JAMA : the Journal of the American Medical Association·S K InouyeJ Concato
Aug 26, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H J AndreyevD Cunningham
Feb 23, 1999·British Journal of Cancer·G MilanoN Renée
Aug 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R S Go, A A Adjei
Dec 30, 1999·The New England Journal of Medicine·L F HutchinsK S Albain
Jan 22, 2000·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·H Deneo-PellegriniM Mendilaharsu
Apr 6, 2000·Journal of the National Cancer Institute·S G DiabG M Clark
Jul 13, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G FrasciM De Lena
Jan 6, 2001·Pharmaceutical Research·J F JenG Hajian
Mar 17, 2001·JAMA : the Journal of the American Medical Association·R YancikJ W Yates
Mar 17, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·L P FriedUNKNOWN Cardiovascular Health Study Collaborative Research Group
Jun 30, 2001·JAMA : the Journal of the American Medical Association·L C WalterK E Covinsky
Oct 24, 2001·Experimental Gerontology·J CampisiM Rubio
Nov 21, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·G Buccheri, D Ferrigno
Dec 12, 2001·British Journal of Clinical Pharmacology·G ToffoliM Boiocchi
Jan 5, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pamela J GoodwinNicky Hood
Mar 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeff A SloanCharles L Loprinzi
Nov 12, 2002·Clinical Pharmacology and Therapeutics·Carolyn L CumminsLeslie Z Benet
Feb 1, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey A MeyerhardtCharles S Fuchs
Apr 8, 2003·Cancer Chemotherapy and Pharmacology·Jing Li, Peter R Gwilt
Oct 17, 2003·British Journal of Cancer·T AparicioUNKNOWN AGEO
Dec 18, 2003·British Journal of Clinical Pharmacology·Kellie A SlavieroLaurent P Rivory
May 26, 2004·International Journal of Pharmaceutics·L Z BenetC Y Wu
May 27, 2004·JAMA : the Journal of the American Medical Association·Jay F PiccirilloEdward L Spitznagel
Jun 4, 2004·The New England Journal of Medicine·Herbert HurwitzFairooz Kabbinavar
Aug 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·William PaoHarold Varmus
Sep 29, 2004·Journal of the American Geriatrics Society·Supriya K Gupta, Elizabeth B Lamont
Dec 1, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xin LiMasatoshi Makuuchi
Feb 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Simron SinghFrances A Shepherd
Feb 16, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Emilio BajettaRoberto Buzzoni
Feb 16, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sae-Won HanNoe Kyeong Kim
Feb 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Albert J ten TijeSharyn D Baker

❮ Previous
Next ❯

Citations

Feb 15, 2013·Cancer Causes & Control : CCC·Paramita DasguptaPeter D Baade
Oct 2, 2013·Clinical Oncology : a Journal of the Royal College of Radiologists·D R SullivanC G Slatore
Apr 4, 2012·Journal of Palliative Medicine·Susan MiesfeldtNancy E Morden
Feb 1, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·X LiM Winget
Oct 2, 2012·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Rodney J Hicks
Jun 15, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Wendy Demark-WahnefriedPamela J Goodwin
Mar 29, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sunny WangLouise C Walter
Jul 4, 2012·International Journal of Molecular Sciences·Ken-Ichi YoshiokaHirobumi Teraoka
Mar 8, 2012·Annals of Surgical Oncology·Gea A GooikerGerrit-Jan Liefers
Mar 19, 2014·Journal of Geriatric Oncology·Christoph BammerReinhard Stauder
Nov 26, 2013·Best Practice & Research. Clinical Anaesthesiology·Sunil Kumar Sahai
Dec 20, 2014·Journal of Cancer Education : the Official Journal of the American Association for Cancer Education·Denalee M O'MalleySuzanne M Miller
Apr 23, 2015·International Reviews of Immunology·Leonardo MirandolaMaurizio Chiriva-Internati
Jan 17, 2012·Leukemia & Lymphoma·Rekha ChandranStephen E Spurgeon
Sep 19, 2012·Seminars in Radiation Oncology·Benjamin Movsas, Martine Extermann
Sep 19, 2012·Seminars in Radiation Oncology·George Rodrigues, Michael Sanatani
Jan 10, 2012·Cancer Treatment Reviews·Frans L OpdamHenk-Jan Guchelaar
Jan 30, 2014·Journal of Cancer Survivorship : Research and Practice·Kimlin AshingArti Hurria
Mar 15, 2016·The Journal of Clinical Investigation·Nobuyoshi KosakaTakahiro Ochiya
Apr 3, 2012·British Journal of Haematology·Paul A Fields, David C Linch
Jul 20, 2011·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A S AliF H Sarkar
Sep 28, 2012·International Journal of Cancer. Journal International Du Cancer·N J van LeersumV E P P Lemmens
May 30, 2013·Asia-Pacific Journal of Clinical Oncology·Jeng-Yeou ChenJen-Der Lin
Jan 22, 2014·The British Journal of Surgery·A C LarsenO Thorlacius-Ussing
Jul 1, 2016·EJC Supplements : EJC : Official Journal of EORTC, European Organization for Research and Treatment of Cancer ... [et Al.]·Joaquim BellmuntMaria De Santis
Jan 17, 2015·Journal of Thrombosis and Haemostasis : JTH·A C LarsenO Thorlacius-Ussing
Jul 12, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Kerri M Clough-GorrRebecca A Silliman
Apr 5, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Yasunori MurataMitsuru Adachi
Aug 21, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Charlotte Rotbøl Bøje
Jan 15, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Eric FrançoisJean-Pierre Gerard
May 1, 2012·Oncology Nursing Forum·Marilyn J Hammer, Joachim G Voss
Nov 29, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B A MahalP L Nguyen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved