Impact of an Antimicrobial Stewardship Bundle for Uncomplicated Gram-Negative Bacteremia

Open Forum Infectious Diseases
Reaghan M EricksonTristan T Timbrook

Abstract

Recent studies in gram-negative bacteremia (GNB) suggest that intravenous (IV) to oral (PO) switch and short treatment durations yield similar clinical outcomes and fewer adverse events. Antimicrobial stewardship program (ASP) bundled initiatives have been associated with improved clinical outcomes for bloodstream infections. This single-center retrospective cohort evaluation included inpatient adults from 11/2014-10/2015 and 10/2017-9/2018 with GNB. The pre-ASP period was before the establishment of an ASP program. In the post period, the ASP promoted IV-to-PO switches, avoidance of repeat blood cultures, and short treatment durations for patients with uncomplicated GNB. The primary outcome was duration of antibiotic therapy. Secondary outcomes included process measures associated with the bundle and clinical outcomes. One hundred thirty-seven patients met criteria for inclusion, with 51 patients in the pre group and 86 patients in the post group. Background characteristics were similar between groups. The median duration of therapy (interquartile range) was 14 (10-16) days in the pre group and 10 days (7-14) in the post group (P < .001). The median day of IV-to-PO switch was day 5 (4-6) in the pre group vs day 4 (3-5) in the ...Continue Reading

Citations

Feb 16, 2021·International Journal of Antimicrobial Agents·Michael T BirrellBenjamin A Rogers
Sep 24, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Valerie M VaughnEmily S Spivak

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