Impact of an antimicrobial stewardship-led intervention for Staphylococcus aureus bacteraemia: a quasi-experimental study

The Journal of Antimicrobial Chemotherapy
Cynthia T NguyenJerod L Nagel

Abstract

Staphylococcus aureus bacteraemia (SAB) carries high rates of morbidity and mortality. Antimicrobial stewardship programmes (ASPs) are well situated to promote adherence to quality performance measures in order to optimize the management of SAB and associated clinical outcomes. This uncontrolled pre-post quasi-experimental study evaluated compliance with an ASP-driven comprehensive care bundle and associated clinical outcomes for patients with SAB. The ASP provided recommendations to prescribers to promote adherence with quality performance measures, which included: initiate effective antibiotics within 24 h of Gram's stain; achieve therapeutic vancomycin trough concentration; provide β-lactam therapy if MSSA; obtain repeat blood cultures every 48 h until clearance; complete appropriate treatment duration; eliminate or debride foci of infection; and obtain an echocardiogram for complicated bacteraemia. One hundred and seventy patients with SAB were included: 82 patients in the pre-intervention group and 88 patients in the ASP-intervention group. Overall bundle adherence to quality performance measures improved from 56.1% (46/82) in the pre-intervention group to 84.1% (74/88) in the ASP-intervention group (P < 0.001), which was ...Continue Reading

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Citations

Aug 16, 2016·Infectious Disease Clinics of North America·Jerod L NagelJason M Pogue
Sep 7, 2016·American Journal of Infection Control·Hanna K WelchGregory A Eschenauer
Aug 9, 2019·The Journal of Antimicrobial Chemotherapy·Jaap Ten OeverAnnelies Verbon
Jun 13, 2020·Journal of the Pediatric Infectious Diseases Society·Elizabeth C LloydAlison C Tribble
Jun 17, 2020·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Tara H LinesGeorge E Nelson
Nov 24, 2016·The Journal of Antimicrobial Chemotherapy·Alan P Johnson

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