Impact of an exercise program on acylcarnitines in obesity: a prospective controlled study.

Journal of the International Society of Sports Nutrition
René Rodríguez-GutiérrezJesus Z Villarreal-Pérez

Abstract

Acylcarnitine (AC) transport dysfunction into the mitochondrial matrix is one of the pathophysiological mechanisms of type 2 diabetes mellitus (DM). The effect of an aerobic exercise (AE) program on this condition in obese subjects without DM is unclear. A prospective, randomized, longitudinal, interventional study in a University Research Center involved a 10-week AE program in 32 women without DM and a body mass index (BMI) greater than 27 kg/m2. (Cases n = 17; Controls n = 15). The primary objective was to evaluate the influence of a controlled AE program on beta-oxidation according to modifications in short, medium, and long-chain ACs. Secondary objectives were to define the behavior of amino acids, and the correlation between these modifications with metabolic and anthropometric markers. The proportion of dropouts was 17% and 6% in controls and cases, respectively. In cases there was a significant reduction in total carnitine (30.40 [95% CI 28.2 to 35.6]) vs. (29.4 [CI 95% 25.1 to 31.7]) p = 0.0008 and long-chain AC C14 (0.06 [95% CI 0.05 to 0.08]) vs. (0.05 [95% CI 0.05 to 0.09]) p = 0.005 and in C18 (0.31 [95% CI 0.27 to 0.45]) vs. (0.28 [95% CI 0.22 to 0.32]) p = 0.03. Free fatty acid levels remained without change duri...Continue Reading

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Citations

Dec 21, 2013·PloS One·Manuel MaiAlexander Benedikt Leichtle
Dec 2, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Edgars LiepinshMaija Dambrova
May 18, 2016·Biology of Sex Differences·Sriram DevanathanKooresh I Shoghi
Jun 18, 2014·The Journal of Clinical Endocrinology and Metabolism·Minako KawaguchiHirotaka Watada
Feb 7, 2020·Animal : an International Journal of Animal Bioscience·J W McFadden

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Methods Mentioned

BETA
biopsies

Software Mentioned

MagPlex
SPSS
MedCalc

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