Impact of an In Situ Component on Outcome After In-Breast Tumor Recurrence in Patients Treated with Breast-Conserving Therapy

Annals of Surgical Oncology
James LairdLior Z Braunstein

Abstract

Among all in-breast tumor recurrences (IBTR) following breast-conserving therapy (BCT), some comprise metachronous new primaries (NPs) while others are true recurrences (TRs). Establishing this distinction remains a challenge. We studied 3932 women who underwent BCT for stage I-III breast cancer from 1998 to 2008. Of these, 115 (2.9%) had an IBTR. Excluding patients with inoperable/unresectable recurrences or simultaneous distant metastases, 81 patients with isolated IBTR comprised the study population. An IBTR was categorized as an NP rather than a TR if it included an in situ component. The log-rank test and Kaplan-Meier method were used to evaluate disease-free survival (DFS) and overall survival (OS), and univariate and multivariate analyses were performed using Cox proportional hazards regression models. At a median of 64.5 months from IBTR diagnosis, 28 of 81 patients had DFS events. Five-year DFS was 43.1% in the TR group (p = 0.0001) versus 80.3% in the NP group, while 5-year OS was 59.7% in the TR group versus 91.7% among those with NPs (p = 0.0011). On univariate analysis, increasing tumor size, high grade, positive margins, lymphovascular invasion, node involvement, lack of axillary surgery, chemotherapy, radiation t...Continue Reading

References

Jan 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A L AbnerJ R Harris
Jan 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B G HafftyC McKhann
Apr 26, 2001·Cancer Treatment Reviews·M ClemonsP Goss
Sep 3, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·I FredrikssonJ Frisell
Oct 7, 2004·International Journal of Radiation Oncology, Biology, Physics·Daniel J KraussFrank A Vicini
Apr 29, 2005·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Yoshifumi KomoikeHideo Inaji
Apr 29, 2005·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Seiichiro NishimuraFujio Kasumi
Aug 24, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A C VoogdUNKNOWN Dutch Study Group on Local Recurrence after Breast Conservation (BORST Group)
May 2, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Irene L WapnirNorman Wolmark
Dec 13, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Antonio C WolffUNKNOWN College of American Pathologists
May 22, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Clifford A HudisJo Anne Zujewski
Dec 18, 2007·The Breast : Official Journal of the European Society of Mastology·J FodorM Kásler
Dec 27, 2007·Journal of the National Cancer Institute·Marc A BolletJean-Paul Thiery
Jan 29, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·D Craig AllredDan Medina
Dec 25, 2009·Breast Cancer Research and Treatment·L BurkhardtA Lebeau
Apr 21, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M Elizabeth H HammondAntonio C Wolff
Feb 4, 2011·International Journal of Radiation Oncology, Biology, Physics·Valerie Panet-RaymondPeter H Watson
Sep 9, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nils D ArvoldJay R Harris
Jun 27, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C van LaarA C Voogd
Oct 29, 2013·International Journal of Radiation Oncology, Biology, Physics·Pauline T TruongAlphonse G Taghian

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Citations

Jun 18, 2021·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Jin WangKevin S Hughes
Oct 27, 2021·International Journal of Radiation Oncology, Biology, Physics·Alan NicholPauline Truong

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