Impact of Anesthesia on Long-term Outcomes in Patients With Supratentorial High-grade Glioma Undergoing Tumor Resection: A Retrospective Cohort Study.

Journal of Neurosurgical Anesthesiology
Jia DongRu-quan Han

Abstract

Intravenous and inhalational anesthesia might have different associations with long-term outcome in cancer patients, with reports of adverse effects of inhalation anesthesia. However, the effects of anesthesia in patients with high-grade glioma (HGG) are not known. This study investigated 154 patients who received propofol and 140 patients who received sevoflurane for maintenance of anesthesia during HGG tumor resection. The primary outcomes were progression-free survival and overall survival. Median progression-free survival was 10 months (interquartile range [IQR], 6 to 18) versus 11 months (IQR 6 to 20; P=0.674), and median overall survival was 18 months (IQR, 11 to 39) versus 18 months (IQR, 10 to 44; P=0.759) in patients maintained with propofol and sevoflurane, respectively. Higher preoperative Karnofsky performance status and postoperative chemotherapy were associated with a reduced hazard of tumor progression or death, whereas higher age-adjusted Charlson comorbidity index and longer duration of anesthesia were associated with an increased hazard of progression or death. World Health Organization tumor classification IV and incomplete tumor resection were associated with an increased hazard of tumor progression but not ...Continue Reading

References

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Citations

Mar 30, 2020·Scientific Reports·Stefan J GrauThorsten Annecke
Mar 19, 2020·Cancer Management and Research·Yichi XuXueqiong Zhu
Sep 15, 2020·Cancer Management and Research·Xiaoqing FanRuiting Wang
Jul 1, 2020·Cell Proliferation·Yichi XuXueqiong Zhu
Nov 19, 2020·Neuro-oncology Advances·Ann PrivorotskiyJuan P Cata
Feb 14, 2021·Acta Anaesthesiologica Scandinavica·Mats Enlund
Oct 27, 2020·Anesthesia and Analgesia·Chun-Yu ChangMing-Chang Kao
Jan 23, 2021·Journal of Neurosurgical Anesthesiology·Jeffrey J Pasternak
May 4, 2021·Current Opinion in Anaesthesiology·Julia DubowitzBernhard Riedel
Jul 15, 2021·Anesthesia and Analgesia·Chun-Yu ChangMing-Chang Kao

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Methods Mentioned

BETA
biopsy
surgical resection

Software Mentioned

SPSS Statistics
R Studio (

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