Impact of anesthetic agents on overall and recurrence-free survival in patients undergoing esophageal cancer surgery: A retrospective observational study

Scientific Reports
In-Jung JunIn-Cheol Choi

Abstract

Given that surgical stress response and surgical excision may increase the likelihood of post-surgery cancer dissemination and metastasis, the appropriate choice of surgical anesthetics may be important for oncologic outcomes. We evaluated the association of anesthetics used for general anesthesia with overall survival and recurrence-free survival in patients who underwent esophageal cancer surgery. Adult patients (922) underwent elective esophageal cancer surgery were included. The patients were divided into two groups according to the anesthetics administered during surgery: volatile anesthesia (VA) or intravenous anesthesia with propofol (TIVA). Propensity score and Cox regression analyses were performed. There were 191 patients in the VA group and 731 in the TIVA group. In the entire cohort, VA was independently associated with worse overall survival (HR 1.58; 95% CI 1.24-2.01; P < 0.001) and recurrence-free survival (HR 1.42; 95% CI 1.12-1.79; P = 0.003) after multivariable analysis adjustment. Similarly, in the propensity score matched cohorts, VA was associated with worse overall survival (HR 1.45; 95% CI 1.11-1.89; P = 0.006) and recurrence-free survival (HR 1.44; 95% CI 1.11-1.87; P = 0.006). TIVA during esophageal can...Continue Reading

References

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Citations

Dec 12, 2018·Anesthesiology·Daniel I Sessler, Bernhard Riedel
Jan 17, 2019·JAMA Surgery·Nicholas J S PerryDaqing Ma
Sep 13, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sophia KoutsogiannakiKoichi Yuki
Jun 21, 2019·Anesthesiology·Zhi-Fu Wu, Hou-Chuan Lai
Jun 23, 2020·Anesthesiology·Frédérique HovaguimianBeatrice Beck-Schimmer
Jul 1, 2020·Cell Proliferation·Yichi XuXueqiong Zhu
Mar 6, 2019·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Andrea YapUNKNOWN Global Onco-Anesthesia Research Collaboration Group
Aug 9, 2020·Local and Regional Anesthesia·Juan P CataMaria F Ramirez
Oct 20, 2020·Cancer Control : Journal of the Moffitt Cancer Center·Aaron R MunceyRobert A Gatenby
Feb 14, 2021·Acta Anaesthesiologica Scandinavica·Mats Enlund
Oct 27, 2020·Anesthesia and Analgesia·Chun-Yu ChangMing-Chang Kao
Jan 7, 2020·British Journal of Anaesthesia·Maximilian S SchaeferMatthias Eikermann
Dec 29, 2020·Anesthesiology·Frédérique HovaguimianBeatrice Beck-Schimmer
Mar 23, 2021·BMC Anesthesiology·Masashi IshikawaDaqing Ma
Mar 26, 2021·BioMed Research International·Koichi Yuki, Miho Shibamura-Fujiogi
Apr 4, 2021·Journal of Clinical Medicine·Mariana Gaya da CostaMichel M R F Struys
May 4, 2021·Current Opinion in Anaesthesiology·Julia DubowitzBernhard Riedel
May 4, 2021·Journal of Cardiothoracic and Vascular Anesthesia·Sarah de La Motte WatsonBen Shelley
Feb 18, 2021·Korean journal of anesthesiology·Azeem AlamDaqing Ma
Jun 9, 2021·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Luke V SelbyDavid J Douin
Oct 17, 2021·Fundamental & Clinical Pharmacology·Priyanka SahaDona Sinha

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Methods Mentioned

BETA
surgical resection
dissection

Software Mentioned

SPSS Statistics
SAS

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