Impact of angiotensin-converting enzyme inhibitors administration prior to acute ischemic stroke onset on in-hospital mortality

Journal of Cardiovascular Pharmacology and Therapeutics
Yahaya HassanSa'ed H Zyoud

Abstract

Angiotensin-converting enzyme inhibitors (ACEIs) have shown promising results in decreasing the incidence and the severity of ischemic stroke in populations at risk and in improving ischemic stroke outcomes. The objectives of this study were to investigate the impact of ACEI use before ischemic stroke onset on in-hospital mortality and to identify the independent predictors of in-hospital mortality among patients with ischemic stroke. A retrospective cohort study of all patients with acute ischemic stroke attending the hospital from June 1, 2008 to November 30, 2008 was performed. Data were collected from medical records and included demographic information, diagnostic information, risk factors, previous ACEI use, and vital discharge status. Statistical Package for Social Sciences (SPSS) version 15 was used for data analysis. A total of 327 patients with acute ischemic stroke were studied, of which 119 (36.4%) had documented previous ACEI use. During the study period, 52 (15.9%) of the patients with acute ischemic stroke died in hospital. In-hospital mortality was significantly lower among patients who were on ACEI before the attack (P = 0.002). The independent predictors for in-hospital mortality among patients with ischemic s...Continue Reading

References

Mar 1, 1997·Stroke; a Journal of Cerebral Circulation·S G WannametheeI J Perry
Jul 9, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·R KranzhöferW Kübler
Jan 20, 2000·The New England Journal of Medicine·G S Francis
Mar 4, 2000·Stroke; a Journal of Cerebral Circulation·H NumminenM Kotila
Feb 7, 2001·Stroke; a Journal of Cerebral Circulation·K JamrozikC S Anderson
Jun 7, 2000·The Journal of Clinical Investigation·A DaughertyL A Cassis
Jan 4, 2001·Stroke; a Journal of Cerebral Circulation·C HajatC D Wolfe
Oct 5, 2002·Stroke; a Journal of Cerebral Circulation·Peter AppelrosAndreas Terént
May 28, 2003·Journal of Clinical Epidemiology·Areej Al-WabilLewis B Morgenstern
Sep 30, 2003·Journal of the American Society of Nephrology : JASN·Stephen L SeligerCatherine O Stehman-Breen
Oct 22, 2003·Lancet·Charles WarlowPeter Sandercock
Jan 5, 2005·Seminars in Vascular Medicine·Antonio PintoGiuseppe Licata
Jun 14, 2005·BMC Neurology·Magdy SelimGottfried Schlaug
Jul 20, 2006·Gerontology·Giovanni ZulianiRenato Fellin
Dec 4, 2008·International Journal of Clinical Pharmacology and Therapeutics·W M Sweileh
Oct 10, 2009·Human & Experimental Toxicology·W S WaringG E Leggett

❮ Previous
Next ❯

Citations

Sep 12, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·J SundbøllHt Sørensen
Jun 12, 2014·PloS One·Marine YeghiazaryanIzabela Figiel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.