Abstract
Antibiotic consumption in the paediatric population is one of the key drivers of the emergence and spread of antimicrobial resistance, which is a serious global threat to public health and clinical medicine. The aims of this study were to investigate systemic antibiotic consumption in school children and to assess the associations among antibiotic consumption, carriage rate and resistance of respiratory pathogens residing in the upper respiratory tract mucosa. In this prospective study, throat and nasopharyngeal swabs from 450 school children, 6-15 years of age (225 healthy children and 225 patients who were ambulatory treated for upper respiratory tract infection), were processed in 2014 in Rijeka, Croatia, and clinical data were obtained via a questionnaire. In total, 17% of the children had consumed an antibiotic in the previous 6 months, including 7% of the healthy children and 27% of the acutely ill patients. The most commonly prescribed antibiotics were amoxicillin (26%), amoxicillin with clavulanic acid (26%) and macrolides (18%). Respiratory pathogens were more frequently isolated from children who had consumed an antibiotic in the previous 6 months [odds ratio (OR) 3.67, P < 0.001]. Antibiotic-resistant bacteria were a...Continue Reading
References
Mar 27, 1998·JAMA : the Journal of the American Medical Association·A C NyquistM A Sande
Sep 4, 1998·BMJ : British Medical Journal·R WiseM Sprenger
Jun 19, 2001·Lancet·O CarsA Melander
May 14, 2005·The Journal of Hospital Infection·K G MakedouS Alexiou-Daniel
May 18, 2005·The Journal of Antimicrobial Chemotherapy·Liselotte HögbergKarl Ekdahl
Mar 3, 2007·The Journal of Antimicrobial Chemotherapy·Hege Salvesen BlixMarit Rønning
Sep 20, 2007·Pharmacoepidemiology and Drug Safety·Larissa GrigoryanUNKNOWN SAR consortium
Sep 25, 2007·European Journal of Clinical Pharmacology·Alessandra RossignoliMaurizio Bonati
Jan 29, 2008·The Lancet Infectious Diseases·S MölstadO Cars
Jun 20, 2008·European Journal of Clinical Pharmacology·Josta de JongLolkje T W de Jong-van den Berg
Apr 8, 2009·European Journal of Public Health·Gaia LusiniLars Bjerrum
Jun 26, 2009·British Journal of Clinical Pharmacology·Antonio ClavennaMaurizio Bonati
Apr 3, 2010·The Journal of Antimicrobial Chemotherapy·Malin AndréCecilia Stålsby Lundborg
May 21, 2010·BMJ : British Medical Journal·Céire CostelloeAlastair D Hay
Oct 5, 2010·The Lancet Infectious Diseases·Vera Vlahović-Palčevski
Jan 15, 2011·Archives of Disease in Childhood·Antonio Clavenna, Maurizio Bonati
Feb 12, 2013·European Journal of Pediatrics·Jakob Holstiege, Edeltraut Garbe
May 15, 2013·SpringerPlus·Jana LassIrja Lutsar
Jan 1, 2014·PloS One·Francesco NapolitanoItalo F Angelillo
Jan 11, 2014·BMC Infectious Diseases·Brian G BellMike Pringle
Jul 7, 2014·BMC Pediatrics·Jakob HolstiegeEdeltraut Garbe
Dec 2, 2014·Therapeutic Advances in Drug Safety·Carl Llor, Lars Bjerrum
Feb 18, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Uri ObolskiLilach Hadany
Mar 15, 2016·Medical History·Christoph Gradmann