Impact of antibiotic consumption on the carriage of antibiotic-resistant bacteria by school children.

European Journal of Public Health
Maja FarkašArjana Tambić Andrašević

Abstract

Antibiotic consumption in the paediatric population is one of the key drivers of the emergence and spread of antimicrobial resistance, which is a serious global threat to public health and clinical medicine. The aims of this study were to investigate systemic antibiotic consumption in school children and to assess the associations among antibiotic consumption, carriage rate and resistance of respiratory pathogens residing in the upper respiratory tract mucosa. In this prospective study, throat and nasopharyngeal swabs from 450 school children, 6-15 years of age (225 healthy children and 225 patients who were ambulatory treated for upper respiratory tract infection), were processed in 2014 in Rijeka, Croatia, and clinical data were obtained via a questionnaire. In total, 17% of the children had consumed an antibiotic in the previous 6 months, including 7% of the healthy children and 27% of the acutely ill patients. The most commonly prescribed antibiotics were amoxicillin (26%), amoxicillin with clavulanic acid (26%) and macrolides (18%). Respiratory pathogens were more frequently isolated from children who had consumed an antibiotic in the previous 6 months [odds ratio (OR) 3.67, P < 0.001]. Antibiotic-resistant bacteria were a...Continue Reading

References

Mar 27, 1998·JAMA : the Journal of the American Medical Association·A C NyquistM A Sande
Sep 4, 1998·BMJ : British Medical Journal·R WiseM Sprenger
Jun 19, 2001·Lancet·O CarsA Melander
May 14, 2005·The Journal of Hospital Infection·K G MakedouS Alexiou-Daniel
Mar 3, 2007·The Journal of Antimicrobial Chemotherapy·Hege Salvesen BlixMarit Rønning
Sep 20, 2007·Pharmacoepidemiology and Drug Safety·Larissa GrigoryanUNKNOWN SAR consortium
Sep 25, 2007·European Journal of Clinical Pharmacology·Alessandra RossignoliMaurizio Bonati
Jun 20, 2008·European Journal of Clinical Pharmacology·Josta de JongLolkje T W de Jong-van den Berg
Apr 8, 2009·European Journal of Public Health·Gaia LusiniLars Bjerrum
Jun 26, 2009·British Journal of Clinical Pharmacology·Antonio ClavennaMaurizio Bonati
Apr 3, 2010·The Journal of Antimicrobial Chemotherapy·Malin AndréCecilia Stålsby Lundborg
Oct 5, 2010·The Lancet Infectious Diseases·Vera Vlahović-Palčevski
Jan 15, 2011·Archives of Disease in Childhood·Antonio Clavenna, Maurizio Bonati
Feb 12, 2013·European Journal of Pediatrics·Jakob Holstiege, Edeltraut Garbe
Jan 1, 2014·PloS One·Francesco NapolitanoItalo F Angelillo
Dec 2, 2014·Therapeutic Advances in Drug Safety·Carl Llor, Lars Bjerrum
Feb 18, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Uri ObolskiLilach Hadany

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Beta-lactamase Inhibitors

Beta-lactamase inhibitors are a class of antibiotics that inhibit beta-lactamases, a family of enzymes involved in bacterial resistance to beta-lactam antibiotics. Here is the latest research.

Beta-lactamase Inhibitors (ASM)

Beta-lactamase inhibitors are a class of antibiotics that inhibit beta-lactamases, a family of enzymes involved in bacterial resistance to beta-lactam antibiotics. Here is the latest research.