Impact of anticholinergic burden on emergency department visits among older adults in Korea: A national population cohort study

Archives of Gerontology and Geriatrics
Sunghee HwangJu-Yeun Lee

Abstract

This study aimed to evaluate the impact of high anticholinergic burden on overall emergency department (ED) visits and ED visits related to adverse effects of anticholinergic drugs among older adults. For this retrospective cohort study, we used claims data from older adults with high representativeness. The average daily Anticholinergic Risk Scale (ARS) score was calculated based on the dosage, treatment duration, and potency of anticholinergic drugs during three months. A high-exposure group (ARS ≥ 2) and a non-exposure group were included in this analysis. The primary outcome was the first ED visit during the follow-up period. Anticholinergic ED visits were defined as ED visits with a main diagnosis of a fall, fracture, dizziness, delirium, constipation, or urinary retention. In total, 118,750 subjects (43.6% male) were included in this study. The mean age was 75.4 ± 6.6 years. The adjusted hazard ratios (aHRs) for all-cause and anticholinergic ED visits among those with high ARS scores were 1.28 (95% CI: 1.20-1.36) and 1.55 (95% CI: 1.38-1.74), respectively. The high-exposure group was at higher risk than the non-exposure group for ED visits for falls or fractures (aHR: 1.31, 95% CI: 1.07-1.60), dizziness (aHR: 1.71, 95% CI...Continue Reading

Citations

Feb 16, 2021·Frontiers in Pharmacology·Joseph O FadareTosin A Agbesanwa
Mar 26, 2021·Archives of Gerontology and Geriatrics·Liang-Kung Chen
Jun 3, 2021·Healthcare·Héctor Rodríguez-RamalloSusana Sánchez-Fidalgo
Jun 10, 2021·Therapeutic Advances in Drug Safety·Carrie StewartPhyo Kyaw Myint
Jul 25, 2020·Journal of the American Medical Directors Association·Angelique EgbertsFrancesco U S Mattace-Raso

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