Impact of anticoagulation on upper-gastrointestinal bleeding in cirrhosis. A retrospective multicenter study

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Federica CeriniJuan Carlos Garcia-Pagán

Abstract

Recent studies have shown that liver cirrhosis (LC) behaves as an acquired hypercoagulable state with increased thrombotic risk. This is why anticoagulation therapy (AT) is now frequently used in these patients. Variceal bleeding is a severe complication of LC. It is unknown whether AT may impact the outcome of bleeding in these patients. Fifty-two patients on AT with upper gastrointestinal bleeding (UGIB) were evaluated. Portal vein thrombosis (PVT) and different cardiovascular disorders (CVDs) were the indication for AT in 14 and 38 patients, respectively. Overall, 104 patients with LC and UGIB not under AT matched for severity of LC, age, sex, source of bleeding, and Sequential Organ Failure Assessment (SOFA) score served as controls. UGIB was attributed to portal hypertension (PH) in 99 (63%) patients and peptic/vascular lesions in 57 (37%). Twenty-six (17%) patients experienced 5-day failure; SOFA, source of UGIB, and PVT, but not AT, were independent predictors of 5-day failure. In addition, independent predictors of 6-week mortality, which was observed in 26 (11%) patients, were SOFA, Charlson Comorbidity index, and use of AT for a CVD. There were no differences between patients with/without AT in needs for rescue therap...Continue Reading

References

Aug 1, 1973·The British Journal of Surgery·R N PughR Williams
Feb 15, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P S KamathW R Kim
Jun 27, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ton LismanFrank W G Leebeek
Jul 26, 2006·The American Journal of Gastroenterology·Patrick G NorthupCarl L Berg
Nov 15, 2006·The American Journal of Gastroenterology·Anne T WolfJohn R Saltzman
Dec 13, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Douglas M HeumanRobert A Fisher
Jan 23, 2008·Journal of Clinical Gastroenterology·George J TheocharisVassiliki Nikolopoulou
Apr 30, 2008·Digestive Diseases and Sciences·David GulleySuthat Liangpunsakul
Oct 30, 2009·Alimentary Pharmacology & Therapeutics·E A TsochatzisA K Burroughs
Mar 5, 2010·The New England Journal of Medicine·Guadalupe Garcia-Tsao, Jaime Bosch
Jun 16, 2010·Journal of Hepatology·Ton LismanUNKNOWN Coagulation in Liver Disease Study Group
Jun 26, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Armando TripodiPier Mannuccio Mannucci
Jul 7, 2011·Journal of Thrombosis and Haemostasis : JTH·A TripodiD C Valla
Sep 8, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jody C OlsonPatrick S Kamath
Feb 1, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·María Gabriela DelgadoJuan Carlos García-Pagán
Feb 6, 2013·The American Journal of Gastroenterology·Grigorios I LeontiadisColin W Howden
Mar 9, 2013·Gastroenterology·Colin John CrooksTimothy Richard Card
Apr 3, 2013·Nature Reviews. Gastroenterology & Hepatology·Julia O'BrienAndrew K Burroughs
Jun 14, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Nicolas M IntagliataPatrick G Northup
Jan 3, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Federica Cerini, Juan Carlos Garcia-Pagán

❮ Previous
Next ❯

Citations

Jan 23, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Carlos Noronha FerreiraJuan-Carlos García-Pagan
Nov 26, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xingshun QiXiaozhong Guo
Apr 29, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Andreas DrolzValentin Fuhrmann
Dec 20, 2015·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Hui ChenJuan Carlos Garcia-Pagán
May 21, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Xiaoming WuJialan Shi
Mar 16, 2017·Clinical and Molecular Hepatology·Filippo LeonardiErica Villa
May 11, 2017·Journal of Clinical Gastroenterology·Michael Loudin, Joseph Ahn
Feb 23, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Marcello BianchiniFilippo Schepis
May 4, 2018·American Journal of Physiology. Gastrointestinal and Liver Physiology·Asmita PantJames P Luyendyk
Apr 11, 2018·Journal of Thrombosis and Haemostasis : JTH·T LismanN M Intagliata
Jun 23, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Maeva GuillaumeAurélie Plessier
Aug 2, 2018·Hepatology International·R Todd Stravitz
Mar 8, 2019·Current Opinion in Gastroenterology·Roula Sasso, Don C Rockey
Mar 11, 2019·Digestive Diseases and Sciences·Carlos Noronha FerreiraJosé Velosa
Feb 13, 2018·Current Opinion in Organ Transplantation·Fanny TuronJuan Carlos García-Pagán
Jun 2, 2020·Haemophilia : the Official Journal of the World Federation of Hemophilia·Andreas TiedeTon Lisman
Nov 23, 2017·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Jae Youn Cheong
Dec 14, 2018·Current Hepatology Reports·Laura TurcoErica Villa
Jun 28, 2016·Clinical Liver Disease·Nicolas M IntagliataStephen H Caldwell
Apr 17, 2019·Clinical Liver Disease·Uyen Kim To, Guadalupe Garcia-Tsao
Feb 11, 2016·The Annals of Pharmacotherapy·Nghi B Ha, Randolph E Regal
May 24, 2017·Gastroenterology Report·Leona von KöckritzMichael Praktiknjo
Dec 12, 2018·Transplantation Direct·Thomas A VerbeekDmitri Bezinover
Dec 12, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Maureen WhitsettLisa B VanWagner
Nov 10, 2016·Clinical Liver Disease·Nicolas M IntagliataStephen H Caldwell
Aug 21, 2020·Seminars in Thrombosis and Hemostasis·Oana Nicoară-FarcăuJuan Carlos García-Pagán
Feb 23, 2019·Expert Review of Gastroenterology & Hepatology·Hong ZhaoLanjuan Li
Aug 21, 2020·Seminars in Thrombosis and Hemostasis·Saro Khemichian, Norah A Terrault
Feb 11, 2020·JHEP Reports : Innovation in Hepatology·Laura TurcoErica Villa
Nov 22, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Patrick G NorthupDominique C Valla
Mar 3, 2021·Journal of Thrombosis and Haemostasis : JTH·Rakavi RathinasamyVirendra Singh
Mar 28, 2021·Seminars in Thrombosis and Hemostasis·Fien A von Meijenfeldt, Ton Lisman
Mar 17, 2021·Journal of Thrombosis and Haemostasis : JTH·Bente P van den BoomTon Lisman
Feb 19, 2021·Clinics and Research in Hepatology and Gastroenterology·Yanying GaoTao Han
Dec 24, 2018·Clinics and Research in Hepatology and Gastroenterology·Michel BergèreJérôme Dumortier
May 12, 2021·Journal of Thrombosis and Haemostasis : JTH·Patrick G NorthupLara N Roberts
Jul 18, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Ton Lisman, Bogdan Procopet

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.