Impact of antimicrobial stewardship managed by clinical pharmacists on antibiotic use and drug resistance in a Chinese hospital, 2010-2016: a retrospective observational study

BMJ Open
Huaguang WangLihong Liu

Abstract

'National Special Stewardship in the Clinical Use of Antibiotics' was put forward in July 2011 in China. We aimed to retrospectively evaluate the impact of antimicrobial stewardship (AMS) managed by clinical pharmacists on antibiotic utilisation, prophylaxis and antimicrobial resistance (AMR). This was a retrospective observational study of trends in antibiotic use and AMR in the context of AMS. Beijing Chaoyang Hospital, a 1400-bed tertiary hospital, in China. Antibiotic prescriptions from 820 doctors included all outpatients (n=17 766 637) and inpatients (n=376 627) during 2010-2016. Bacterial resistance data were from all inpatients (n=350 699) during 2011-2016. Multiaspect intervention measures were implemented by clinical pharmacists (13 persons), for example, formulating the activity programme and performance management, advising on antibacterial prescriptions and training. The proportion of antibiotic prescriptions among outpatients and inpatients, intensity of consumption in defined daily dose (DDD)/100 bed-days, antibiotic prophylaxis in type I incision operations and resistance rates of Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa were retrospectively analysed. The proportion of antibiotic prescr...Continue Reading

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Citations

May 14, 2020·Journal of Clinical Pharmacy and Therapeutics·Yanting WangGuohui Li
Jul 4, 2019·BMC Veterinary Research·John E EkakoroChika C Okafor
Jun 18, 2020·Open Forum Infectious Diseases·Kevin LinBonnie C Prokesch
Feb 4, 2021·The Journal of Antimicrobial Chemotherapy·Elena CarraraCristina Mussini
Feb 13, 2021·Antibiotics·Christian KranjecDzung B Diep
Jan 7, 2021·Infection and Drug Resistance·Md Anwarul Azim MajumderMarquita Gittens-St Hilaire

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Methods Mentioned

BETA
coronary artery bypass

Software Mentioned

CHINET
AMS
SAS

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