Impact of Antiplatelets and Anticoagulants on the Prognosis of Intracerebral Hemorrhage

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Masaaki HokariKoji Itamoto

Abstract

Intracerebral hemorrhage (ICH) associated with antithrombotic therapy (AT) is becoming more common as the use of those medications increases in the aging population. This study included 490 consecutive patients hospitalized for nontraumatic ICH in a single center during an 8-year period, which was subdivided into former (2008-2011) and latter (2012-2015). Patients were classified into those with no antithrombotic drugs (NATs) and those with AT. The AT group was divided into 4 subgroups according to medications: antiplatelet (AP1), multiple antiplatelets (AP2), anticoagulant (AC), and antiplatelet and anticoagulant (APC). We evaluated the clinical characteristics and prognosis and compared the number of patients on AT between the former and latter groups. There were 125 patients treated with AT (25.5%), including 50 (10.2%) on AP1, 14 (2.9%) on AP2, 32 (6.5%) on ACs, and 29 (5.9%) on APCs. Compared with the former group, the latter group had a higher number of patients on AT (19.3% versus 31.7%), AP1 (9.8% versus 10.6%), AP2 (1.6% versus 4.1%), ACs (4.9% versus 8.1%), and APCs (2.90% versus 8.9%). Compared with the NAT group, the patients in the AT group had a larger ICH volume, more frequent hematoma expansion, and higher rate ...Continue Reading

Citations

Feb 11, 2021·Stroke; a Journal of Cerebral Circulation·Trine Apostolaki-HanssonJesper Petersson
Feb 16, 2021·Journal of the American Heart Association·Zhe Kang LawNikola Sprigg

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