Impact of apolipoprotein(a) phenotypes on long-term renal transplant survival.

Journal of the American Society of Nephrology : JASN
Friederike WahnU Querfeld

Abstract

The long-term success of renal transplantation is limited because of chronic rejection (CR), which shows histologic parallels to atherosclerosis. Lipoprotein(a) [Lp(a)] is an independent risk factor for atherosclerosis, but its role in CR has not been investigated. Plasma levels of Lp(a) are determined mainly by the inherited isoform (phenotype) of apolipoprotein(a) [apo(a)] and show an inverse correlation with the molecular weight of apo(a). Apo(a) isoforms were identified in frozen sera of 327 patients who received a renal transplant during 1982 to 1992. Long-term graft survival in recipients with high molecular weight (HMW) or low molecular weight (LMW) apo(a) phenotypes were compared retrospectively. Mean (95% confidence interval) transplant survival was 12.8 yr (range, 11.9 to 13.6 yr) in patients with HMW and 11.9 yr (range, 10.8 to 13.1 yr) in patients with LMW apo(a) phenotypes (P = 0.2065). In patients who were 35 yr or younger at the time of transplantation, mean transplant survival was more than 3 yr longer in recipients with HMW apo(a) phenotypes compared with those with LMW apo(a) phenotypes (13.2 yr [range, 12.1 to 14.4 yr] versus 9.9 yr (range, 8.5 to 11.5 yr); P = 0.0156). In a Cox's proportional hazards regress...Continue Reading

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Citations

May 10, 2002·Pediatric Transplantation·Uwe Querfeld, Friederike Wahn
Aug 2, 2002·Current Opinion in Lipidology·Karam M Kostner, Gerhard M Kostner
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Oct 28, 2003·Transplantation·Mahmoud SadeghiGerhard Opelz
Jun 24, 2004·Dementia and Geriatric Cognitive Disorders·Enzo EmanueleDiego Geroldi
Aug 4, 2005·Applied Health Economics and Health Policy·Laura GinnellySue Golder

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