PMID: 18413070Apr 17, 2008Paper

Impact of assisted hatching on fresh and frozen-thawed embryo transfer cycles: a prospective, randomized study

Reproductive Biomedicine Online
Hong-Shan GeJin-Jun Lin

Abstract

The aim of this study was to determine if assisted hatching (AH) could improve the rates of pregnancy and implantation for both fresh and frozen-thawed embryo transfer cycles. A total of 760 fresh embryo transfer cycles and 200 frozen-thawed embryo transfer cycles were randomly assigned to either the treatment group (AH) or the control group (no AH). Zona thinning by laser was performed just before embryo transfer. In fresh embryo transfer cycles, the AH group and control group results were comparable. There were no significant differences in the rates of positive human chorionic gonadotrophin (HCG; 47.5 versus 48.8%), clinical pregnancy (42.4 versus 42.6%), or implantation (26.3 versus 25.2%) between the two groups. However, in frozen-thawed embryo transfer cycles, the rates of positive HCG (32.0 versus 17.0%), clinical pregnancy (25.0 versus 14.0%) and implantation (16.7 versus 7.3%) were significantly greater in the AH group than in the control group (P &lt: 0.05). The results of this investigation show that in the fresh embryo transfer cycles, laser-assisted hatching by zona thinning has no impact on the rates of positive HCG, clinical pregnancy and implantation, whereas in frozen-thawed cycles, assisted hatching by zona th...Continue Reading

References

Apr 13, 2005·Reproductive Biomedicine Online·C G PetersenJ G Franco
Aug 10, 2006·Reproductive Biomedicine Online·T S GhobaraJ M Jenkins
Dec 16, 2006·Reproductive Biomedicine Online·Claudia Guilhermino PetersenJose Gonçalves Franco
Jul 12, 2007·Reproductive Biomedicine Online·Kenichiro HiraokaKazuo Kinutani

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Citations

Oct 16, 2009·Journal of Assisted Reproduction and Genetics·Kenichiro HiraokaKazuo Kinutani
May 15, 2010·Journal of Assisted Reproduction and Genetics·Pelin KutluOmer Faruk Vanlioglu
Apr 9, 2011·Human Reproduction Update·Wellington P MartinsCarolina O Nastri
Mar 21, 2013·Reproductive Biology and Endocrinology : RB&E·Chanchai ChailertTeraporn Vutyavanich
Sep 9, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Yi-Fan GuGuang-Xiu Lu
Jul 28, 2011·Taiwanese Journal of Obstetrics & Gynecology·Mahnaz AshrafiTahereh Madani
Feb 2, 2010·Reproductive Biomedicine Online·Mojtaba Rezazadeh ValojerdiBahar Movaghar
Mar 10, 2016·Zygote : the Biology of Gametes and Early Embryos·Katalin KanyoJanos Konc
Jul 15, 2015·Clinical and Experimental Reproductive Medicine·Young Seok LeeBo Sun Joo
Jun 22, 2014·Fertility and Sterility·UNKNOWN Practice Committee of the American Society for Reproductive Medicine, UNKNOWN Practice Committee of the Society for Assisted Reproductive Technology
Jul 1, 2016·Clinical and Experimental Reproductive Medicine·Yong Soo HurJin Ho Lim
Jan 20, 2018·Journal of Assisted Reproduction and Genetics·Alessandra AlteriPatrizia Rubino
Dec 14, 2012·The Cochrane Database of Systematic Reviews·Sarah-Kate CarneyLinsey Nelson
May 23, 2014·Reproductive Medicine and Biology·Maki GotoFumitaka Kikkawa
Mar 18, 2021·The Cochrane Database of Systematic Reviews·Lauren LaceyM Ahsan Akhtar

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