Impact of atopy on risk of glioma: a Mendelian randomisation study

BMC Medicine
Linden Disney-HoggRichard S Houlston

Abstract

An inverse relationship between allergies with glioma risk has been reported in several but not all epidemiological observational studies. We performed an analysis of genetic variants associated with atopy to assess the relationship with glioma risk using Mendelian randomisation (MR), an approach unaffected by biases from temporal variability and reverse causation that might have affected earlier investigations. Two-sample MR was undertaken using genome-wide association study data. We used single nucleotide polymorphisms (SNPs) associated with atopic dermatitis, asthma and hay fever, IgE levels, and self-reported allergy as instrumental variables. We calculated MR estimates for the odds ratio (OR) for each risk factor with glioma using SNP-glioma estimates from 12,488 cases and 18,169 controls, using inverse-variance weighting (IVW), maximum likelihood estimation (MLE), weighted median estimate (WME) and mode-based estimate (MBE) methods. Violation of MR assumptions due to directional pleiotropy were sought using MR-Egger regression and HEIDI-outlier analysis. Under IVW, MLE, WME and MBE methods, associations between glioma risk with asthma and hay fever, self-reported allergy and IgE levels were non-significant. An inverse rel...Continue Reading

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Citations

Jul 14, 2019·Neuro-oncology·Quinn T OstromMelissa L Bondy
May 21, 2020·Blood Advances·Molly WentRichard S Houlston
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Methods Mentioned

BETA
genotyping

Related Concepts

Mixed Gliomas
Genome-Wide Association Study
Mendelian Randomization Analysis
Epidemiologic Studies
Asthma
Dermatitis, Atopic
Glioma
Hypersensitivity
Immunoglobulins
Regression Analysis

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