Impact of attenuation correction strategies on the quantification of High Resolution Research Tomograph PET studies

Physics in Medicine and Biology
Floris H P van VeldenRonald Boellaard

Abstract

In this study, the quantitative accuracy of different attenuation correction strategies presently available for the High Resolution Research Tomograph (HRRT) was investigated. These attenuation correction methods differ in reconstruction and processing (segmentation) algorithms used for generating a micro-image from measured 2D transmission scans, an intermediate step in the generation of 3D attenuation correction factors. Available methods are maximum-a-posteriori reconstruction (MAP-TR), unweighted OSEM (UW-OSEM) and NEC-TR, which transforms sinogram values back to their noise equivalent counts (NEC) to restore Poisson distribution. All methods can be applied with or without micro-image segmentation. However, for MAP-TR a micro-histogram is a prior during reconstruction. All possible strategies were evaluated using phantoms of various sizes, simulating preclinical and clinical situations. Furthermore, effects of emission contamination of the transmission scan on the accuracy of various attenuation correction strategies were studied. Finally, the accuracy of various attenuation corrections strategies and its relative impact on the reconstructed activity concentration (AC) were evaluated using small animal and human brain studi...Continue Reading

References

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Citations

Dec 2, 2009·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Jin Su KimDong Soo Lee
Jul 17, 2014·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Floris H P van VeldenMarc C Huisman
Jan 10, 2012·Nuclear Medicine and Biology·Joost VerbeekAdriaan A Lammertsma
May 11, 2013·IEEE Transactions on Medical Imaging·Sune H KellerMerence Sibomana
Apr 1, 2017·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Julia G MannheimBernd J Pichler
Oct 22, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jurgen E M MourikRonald Boellaard
Nov 7, 2014·Metabolomics : Official Journal of the Metabolomic Society·Lucille StuaniAlain Perret
Nov 13, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Stina SyvänenRob A Voskuyl
Apr 18, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Floris H P van VeldenRonald Boellaard
Apr 17, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Young-Don SonZang-Hee Cho

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