Impact of automation on mass spectrometry

Clinica Chimica Acta; International Journal of Clinical Chemistry
Yan Victoria Zhang, Alan L Rockwood

Abstract

Mass spectrometry coupled to liquid chromatography (LC-MS and LC-MS/MS) is an analytical technique that has rapidly grown in popularity in clinical practice. In contrast to traditional technology, mass spectrometry is superior in many respects including resolution, specificity, multiplex capability and has the ability to measure analytes in various matrices. Despite these advantages, LC-MS/MS remains high cost, labor intensive and has limited throughput. This specialized technology requires highly trained personnel and therefore has largely been limited to large institutions, academic organizations and reference laboratories. Advances in automation will be paramount to break through this bottleneck and increase its appeal for routine use. This article reviews these challenges, shares perspectives on essential features for LC-MS/MS total automation and proposes a step-wise and incremental approach to achieve total automation through reducing human intervention, increasing throughput and eventually integrating the LC-MS/MS system into the automated clinical laboratory operations.

References

Nov 1, 1996·Nature Biotechnology·M A ClaydonD B Gordon
Jun 6, 2003·The New England Journal of Medicine·Bridget WilckenKevin Carpenter
Mar 16, 2007·Journal of Pharmaceutical and Biomedical Analysis·Raymond Naxing XuTawakol A El-Shourbagy
Mar 23, 2007·Analytical and Bioanalytical Chemistry·Hans H Maurer
Apr 1, 2008·Clinical Biochemistry·Michael Vogeser, Christoph Seger
May 9, 2009·Clinical Chemistry·Graham D Carter
Aug 27, 2009·Mass Spectrometry Reviews·Mark M KushnirJonas Bergquist
Apr 13, 2010·Clinical Biochemistry·Kimberly L NapoliDonald P Cooper
May 7, 2010·The New England Journal of Medicine·Eric G PoonTejal K Gandhi
Jul 6, 2010·Clinical Biochemistry·Michael Vogeser, Fabian Kirchhoff
Aug 13, 2010·Clinical Chemistry·Marion L SnyderCorinne R Fantz
Aug 27, 2010·Clinical Chemistry·Charles D Hawker
Feb 10, 2011·Annals of Clinical Biochemistry·John W Honour
Oct 15, 2011·Clinical Chemistry·Daniel M LevineDavid W Holt
Nov 22, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Pierre-Olivier HétuBernard Vinet
Dec 27, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Johannes M W van den Ouweland, Ido P Kema
Nov 20, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jane A DickersonNoah G Hoffman
Oct 15, 2014·Annals of Clinical Biochemistry·Joanne E AdawayLaura J Owen

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Citations

Apr 12, 2016·Proteomics. Clinical Applications·Bassel SabbaghPeter Findeisen
Jun 5, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Michael E LassmanOmar F Laterza
Feb 21, 2019·Archives of Pathology & Laboratory Medicine·Min YuJames H Harrison
Feb 1, 2020·International Anesthesiology Clinics·A Zara HerskovitsLynne Uhl
Apr 7, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Giorgia AntonelliMario Plebani
Mar 20, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Gian Luca SalvagnoGiuseppe Lippi

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