Impact of avolition and cognitive impairment on functional outcome in first-episode schizophrenia-spectrum disorder: a prospective one-year follow-up study

Schizophrenia Research
Wing Chung ChangEric Yu Hai Chen

Abstract

Previous research investigating the relationships between avolition, cognition and functioning in schizophrenia mostly focused on chronic samples and were cross-sectional in design. Impacts of avolition and cognition on longitudinal functional outcome in first-episode patients are under-studied. We assessed 114 Chinese aged 18-55 years presenting with first-episode schizophrenia-spectrum disorder aiming to identify baseline predictors of 1-year functional outcome. Results showed that both avolition and global cognition independently predicted functioning, with avolition being the strongest predictor above and beyond cognition and other symptom dimensions. Our findings indicate the central role of in determining longitudinal functional status in the early illness stage.

References

Dec 1, 1976·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·H E Nelson
Mar 1, 1992·Schizophrenia Research·H HäfnerW van der Heiden
Aug 1, 1991·Psychiatry Research·R S MarinS Firinciogullari
Jan 1, 1987·Schizophrenia Bulletin·S R KayL A Opler
Jul 1, 1982·Archives of General Psychiatry·N C Andreasen
Mar 22, 2003·Schizophrenia Research·Robin EmsleyUNKNOWN RIS-INT-35 Early Psychosis Global Working Group
Nov 8, 2008·Schizophrenia Bulletin·Lex WunderinkDurk Wiersma
Oct 20, 2009·Schizophrenia Research·G FoussiasG Remington
Nov 3, 2009·Psychiatric Services : a Journal of the American Psychiatric Association·Ann FaerdenIngrid Melle
Dec 2, 2009·Schizophrenia Research·Ann FaerdenIngrid Melle
Jul 27, 2011·Schizophrenia Research·George KonstantakopoulosAntonis M Politis
Jan 31, 2012·Schizophrenia Research·Julie EvensenThomas McGlashan
Feb 9, 2012·The Australian and New Zealand Journal of Psychiatry·Wing Chung ChangEric Y Chen
May 24, 2012·Acta Psychiatrica Scandinavica·S VermaS A Chong
Aug 6, 2013·Psychiatry Research·Gagan FervahaGary Remington
Jan 1, 2014·Schizophrenia Bulletin·Gregory P StraussJames M Gold
Oct 3, 2014·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Silvana GalderisiUNKNOWN Italian Network For Research on Psychoses
Jun 8, 2015·Biological Psychiatry·James M GoldMichael J Frank

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Citations

Jan 4, 2017·European Psychiatry : the Journal of the Association of European Psychiatrists·W C ChangE Y H Chen
Dec 2, 2017·Brain : a Journal of Neurology·Mathias PessiglioneRaphaël Le Bouc
Feb 27, 2019·European Archives of Psychiatry and Clinical Neuroscience·Luk MskChen Eyh
Aug 26, 2016·Schizophrenia Bulletin·David R RoalfBruce I Turetsky
Jul 10, 2020·Journal of Autism and Developmental Disorders·L BoadaM Parellada
Jun 24, 2018·European Archives of Psychiatry and Clinical Neuroscience·Wing Chung ChangEric Yu Hai Chen
May 1, 2020·Schizophrenia Research·Mariia KaliuzhnaStefan Kaiser
Feb 3, 2019·Schizophrenia Research·Donald C GoffJingping Zhao
Jun 20, 2021·Social Psychiatry and Psychiatric Epidemiology·Yohannes Gebreegziabhere HaileAtalay Alem

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