Impact of B-type natriuretic peptide level on the risk of left atrial appendage thrombus in patients with nonvalvular atrial fibrillation: a prospective study

Cardiovascular Ultrasound
Rojina PantRami Doukky

Abstract

The impact of B-type natriuretic peptide (BNP) level on the risk of left atrial appendage (LAA) thrombus in patients with nonvalvular atrial fibrillation (NVAF) has not been prospectively studied. In two academic medical centers, we obtained BNP levels immediately prior to transesophageal echocardiogram performed to exclude LAA thrombus in patients with NVAF. Among 261 subjects (mean age 65 ± 12 years; 30 % women) with NVAF, 17 (6.5 %) had LAA thrombus and 85 (32.6 %) had at least mild spontaneous echo contrast (SEC). Mean BNP level was significantly higher in patients with LAA thrombus [775 ± 678 vs. 384 ± 537, P = 0.001]. Receiver operator characteristics analysis demonstrated that BNP has a good discriminatory capacity for LAA thrombus (area under the curve, 0.74; 95 % confidence interval [CI], 0.63-0.85; P = 0.001); BNP ≥ 67 pg/mL was 100 % sensitive and 20 % specific for LAA thrombus. Multivariate logistic regression analysis demonstrated that BNP was not independently associated with LAA thrombus (odds-ratio, 1.05 per 100 pg/mL increment; CI, 0.99-1.12; P = 0.127) after adjusting for CHA2DS2-VASc score; while the latter was independently associated with LAA thrombus after adjusting for BNP level (odds-ratio, 1.46 per CHA2...Continue Reading

References

Oct 1, 1989·Cardiovascular Research·F SoltiA Juhász-Nagy
Feb 15, 1986·The American Journal of Cardiology·R B DevereuxN Reichek
Jan 1, 1986·Journal of the American College of Cardiology·W AschenbergW Bleifeld
Sep 1, 1994·Journal of the American College of Cardiology·D Y LeungW F Walsh
Jun 13, 2001·JAMA : the Journal of the American Medical Association·B F GageM J Radford
Feb 13, 2004·The New England Journal of Medicine·Thomas J WangRamachandran S Vasan
Jun 15, 2004·The American Journal of Cardiology·Beata Wozakowska-Kapłon
Sep 13, 2005·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Peter BernhardtHeyder Omran
Jun 21, 2006·European Heart Journal·Jens Peter GoetzeJesper Hastrup Svendsen
Nov 23, 2006·Journal of the American College of Cardiology·Oussama M WazniAllan L Klein
Jun 24, 2009·Pacing and Clinical Electrophysiology : PACE·Dawid BakowskiGrzegorz Opolski
Jan 7, 2015·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Roberto M LangJens-Uwe Voigt

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Citations

Dec 18, 2016·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Rami DoukkyMita Patel
Nov 28, 2020·Frontiers in Cardiovascular Medicine·Ziliang SongXu Liu
May 17, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Meng ZhangAijun Ma

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