Impact of B-Type Natriuretic Peptide Level on Risk Stratification of Thromboembolism and Death in Patients With Nonvalvular Atrial Fibrillation - The Hokuriku-Plus AF Registry

Circulation Journal : Official Journal of the Japanese Circulation Society
Kenshi HayashiHokuriku-Plus AF Registry Investigators

Abstract

B-type natriuretic peptide (BNP) may be a predictor of stroke risk in patients with nonvalvular atrial fibrillation (NVAF); because heart failure is associated with the incidence of stroke in AF patients. However, limited data exist regarding the association between BNP at baseline and risks of thromboembolic events (TE) and death in NVAF patients. We prospectively studied 1,013 NVAF patients (725 men, 72.8±9.7 years old) from the Hokuriku-plus AF Registry to determine the relationship between BNP at baseline and prognosis among Japanese NVAF patients. During the follow-up period (median, 751 days); 31 patients experienced TE and there were 81 cases of TE/all-cause death. For each endpoint we constructed receiver-operating characteristic curves that gave cutoff points of BNP for TE (170 pg/mL) and TE/all-cause death (147 pg/mL). Multivariate analysis with the Cox-proportional hazards model indicated that high BNP was significantly associated with risks of TE (hazard ratio [HR] 3.86; 95% confidence interval [CI] 1.83-8.67; P=0.0003) and TE/all-cause death (HR 2.27; 95% CI 1.45-3.56; P=0.0003). Based on the C-index and net reclassification improvement, the addition of BNP to CHA2DS2-VASc statistically improved the prediction of T...Continue Reading

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Citations

Apr 16, 2020·JAMA Network Open·Ken OkumuraUNKNOWN J-RISK AF Research Group
Apr 1, 2020·Journal of Atherosclerosis and Thrombosis·Hirofumi Tomita
Jul 29, 2019·Current Cardiology Reports·Pooja S Jagadish, Rajesh Kabra
Jul 28, 2020·Circulation Journal : Official Journal of the Japanese Circulation Society·Nobuhiro MurataUNKNOWN SAKURA AF Registry Investigators
Nov 11, 2020·Clinical and Experimental Pharmacology & Physiology·Hong DuHuiyu Shao
Nov 28, 2020·Frontiers in Cardiovascular Medicine·Ziliang SongXu Liu
Feb 9, 2021·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Juqian ZhangTatjana S Potpara
Mar 26, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·Ken OkumuraUNKNOWN J-RISK AF Research Group

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