Impact of bariatric surgery on apolipoprotein C-III levels and lipoprotein distribution in obese human subjects

Journal of Clinical Lipidology
Marie MaraninchiRené Valéro

Abstract

Elevated apolipoprotein C-III (apoC-III) has been postulated to contribute to the atherogenic dyslipidemia seen in obesity and insulin-resistant states, mainly by impairing plasma triglyceride-rich lipoprotein (TRL) metabolism. Bariatric surgery is associated with improvements of several obesity-associated metabolic abnormalities, including a reduction in plasma triglycerides (TGs) and an increase in plasma high-density lipoprotein cholesterol (HDL-C). We investigated the specific effect of bariatric surgery on apoC-III concentrations in plasma, non-HDL, and HDL fractions in relation to lipid profile parameters evolution. A total of 132 obese subjects undergoing bariatric surgery, gastric bypass (n = 61) or sleeve gastrectomy (n = 71), were studied 1 month before surgery and 6 and 12 months after surgery. Plasma apoC-III, non-HDL-apoC-III, and HDL-apoC-III concentrations were markedly reduced after surgery and strongly associated with reduction in plasma TG. This decrease was accompanied by a redistribution of apoC-III from TRL to HDL fractions. In multivariate analysis, plasma apoC-III was the strongest predictor of TG reduction after surgery, and the increase of HDL-C was positively associated with plasma adiponectin and nega...Continue Reading

Citations

Nov 29, 2020·Metabolism: Clinical and Experimental·Marie-Eve PichéPaul Poirier
Mar 22, 2021·The Surgical Clinics of North America·Vance L AlbaughAli Aminian
Aug 11, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·Magalí BarchukGabriela Berg
Sep 1, 2021·Journal of Clinical Lipidology·Marie MaraninchiRené Valéro

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