Impact of Baseline Anemia in Patients With Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention: A Prespecified Analysis From the VALIDATE-SWEDEHEART Trial

Journal of the American Heart Association
Axel WesterSasha Koul

Abstract

Background The impact of baseline anemia in a contemporary acute coronary syndrome (ACS) population undergoing percutaneous coronary intervention in the era of predominant radial artery access, potent P2Y12 inhibition, and rare use of glycoprotein IIb/IIIa inhibitors has not been adequately studied. Methods and Results ACS patients who underwent percutaneous coronary intervention between 2014 and 2016 in the VALIDATE-SWEDEHEART (Bivalirudin Versus Heparin in ST-Segment and Non-ST-Segment Elevation Myocardial Infarction in Patients on Modern Antiplatelet Therapy in the Swedish Web System for Enhancement and Development of Evidence-Based Care in Heart Disease Evaluated According to Recommended Therapies Registry) trial without missing values for hemoglobin were included (n=5482). Mortality, myocardial reinfarction, and major bleeding at 180 days were assessed using Cox regression models and propensity score matching. All studied comorbidities were more common in ACS patients who had anemia (n=792). ACS patients with anemia had higher rates of 180-day mortality (6.9% versus 2.1%; hazard ratio, 1.9; 95% CI, 1.3-2.7; P<0.001), myocardial reinfarction (4.3% versus 1.9%; hazard ratio, 1.7; 95% CI, 1.1-2.7; P=0.013), and major bleeding...Continue Reading

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Citations

Jan 11, 2020·Endocrinology, Diabetes & Metabolism·Raphael Romano BrunoChristian Jung
Jan 22, 2021·Journal of Cardiovascular Electrophysiology·Samuel J TuChristopher X Wong
Apr 6, 2021·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Yu ZhaoYi Li
May 2, 2021·The Egyptian Heart Journal : (EHJ) : Official Bulletin of the Egyptian Society of Cardiology·Ahmed HusseinHossam Eldin M Mahmoud
Apr 29, 2021·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Victor RazukGeorge D Dangas
Aug 31, 2021·European Heart Journal Supplements : Journal of the European Society of Cardiology·Adriano MurroneDomenico Gabrielli
Oct 7, 2021·Journal of the American Heart Association·Axel WesterSasha Koul
Nov 21, 2021·BMC Cardiovascular Disorders·Huilin HuLiang Shen

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Methods Mentioned

BETA
coronary artery bypass

Software Mentioned

Vifor
R ( R Foundation for
VALIDATE
SWEDEHEART
Stata
SPSS
GraphPad Prism

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