Impact of bisphenol-A on early embryonic development and reproductive maturation

Reproductive Toxicology
Siddharth Ramakrishnan, Nancy L Wayne

Abstract

Bisphenol-A (BPA) is a synthetic estrogen and monomer component of polycarbonate plastics and epoxy resins that are widely used in the production of food and beverage containers. It leaches into our food and drink at concentrations shown to have biological consequences. Here we show that exposure to low levels of BPA accelerated early embryonic development within 24h of exposure, attenuated body growth, and advanced the times of hatching and reproductive maturation in medaka fish (Oryzias latipes). The acceleration in embryonic development and time to hatch were blocked by the thyroid-hormone receptor (TH-R) antagonist amiodarone, suggesting that BPA alters global developmental timing through a thyroid-hormone pathway. Our results are likely to have broad implications regarding the effects of plastic-derived contaminants on embryonic and reproductive development.

References

Jun 1, 1995·Environmental Health Perspectives·J A BrotonsN Olea
Nov 3, 1998·Environmental Health Perspectives·J Ashby, H Tinwell
Apr 25, 2000·Biochemical and Biophysical Research Communications·Y TakaiY Taketani
Aug 2, 2001·Environmental Science & Technology·P SohoniJ P Sumpter
Apr 20, 2002·Differentiation; Research in Biological Diversity·Yi-Wen Liu, Woon-Khiong Chan
Nov 6, 2002·Environmental Health Perspectives·Gilbert SchönfelderIbrahim Chahoud
Apr 5, 2003·Current Biology : CB·Patricia A HuntTerry J Hassold
Jul 5, 2003·Environmental Health Perspectives·Kembra L HowdeshellWade V Welshons
Jun 24, 2004·Mechanisms of Development·Takashi Iwamatsu
Jun 11, 2005·Human Reproduction·Mayumi Sugiura-OgasawaraKaoru Suzumori
Jun 24, 2005·The Science of the Total Environment·Jinmiao Zha, Zijian Wang
Nov 1, 2005·Environmental Research·Frederick S vom Saal, Wade V Welshons
Feb 10, 2006·International Journal of Andrology·Marcia E Herman-Giddens
Jun 6, 2006·Water Science and Technology : a Journal of the International Association on Water Pollution Research·M IkeM Fujita
Jun 20, 2006·Molecular and Cellular Endocrinology·Maricel V MaffiniAna M Soto
Jul 25, 2006·Toxicology·Jeong-Hun KangYoshiki Katayama
Jul 3, 2007·Reproductive Toxicology·D Andrew CrainLouis J Guillette
Sep 11, 2007·Reproductive Toxicology·Laura N VandenbergWade V Welshons

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Citations

Jun 22, 2012·Environmental Science and Pollution Research International·Qiansheng HuangSijun Dong
Jul 22, 2010·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Jae-Sung RheeJae-Seong Lee
Jan 27, 2009·Biochemical and Biophysical Research Communications·Jianzhou CuiYoshitaka Nagahama
Dec 8, 2010·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Mari S GolubJames M Donald
May 23, 2014·Bulletin of Environmental Contamination and Toxicology·Liwei SunZhengwei Fu
Sep 3, 2013·Reproductive Toxicology·Johanna R Rochester
Feb 18, 2015·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Lori CruzeLouis J Guillette
Jan 10, 2012·Toxicology and Applied Pharmacology·Zhi-Guo ShengBen-Zhan Zhu
Apr 28, 2016·Epigenetics : Official Journal of the DNA Methylation Society·L V LaingE M Santos
Jun 22, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R G Ahmed
Dec 18, 2015·Dose-response : a Publication of International Hormesis Society·Laura Canesi, Elena Fabbri
Jun 6, 2009·Archives of Environmental Contamination and Toxicology·Ching-Yi HorngWenjau Lee
Aug 5, 2020·Journal of Neuroendocrinology·Pascal CoumailleauThierry D Charlier
Apr 12, 2019·Reproduction in Domestic Animals = Zuchthygiene·Dan SongFangxiong Shi
Mar 30, 2021·Frontiers in Endocrinology·Giada FrenzilliNoomi Asker
Jan 29, 2011·BMC Developmental Biology·Yann GibertVincent Laudet
Oct 4, 2021·Environmental Science and Pollution Research International·Shanthanagouda Admane HoleyappaRam Saran Sethi

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