Impact of blastocyst transfer on offspring sex ratio and the monozygotic twinning rate: a systematic review and meta-analysis

Fertility and Sterility
Hye Jin ChangSeok Hyun Kim

Abstract

To determine the sex ratio and risk of monozygotic twinning (MZT) after blastocyst transfer compared with cleavage-stage embryo transfer (ET) in fresh IVF cycles. Systematic review and meta-analysis. University hospital center for reproductive medicine and IVF. Results of all reports from January 1995 to November 2007 with women undergoing nondonor fresh IVF. The sex ratio of 2,587 offspring and MZT rate in 40,917 cycles were included. Cleavage or blastocyst stage for embryo transfer. Sex ratio and rate of MZT. A meta-analysis was performed using four studies for sex ratio and nine studies for MZT. The results of the meta-analysis using a fixed effect model demonstrated a higher male-female ratio after blastocyst transfer compared with cleavage-stage ET (odds ratio [OR] 1.29, 95% confidence interval [CI] 1.10-1.51), and this difference was statistically significant. The risk of MZT after blastocyst transfer was significantly higher compared with cleavage-stage ET (OR 3.04, 95% CI 1.54-6.01). The combined data presented in this meta-analysis suggest that blastocyst transfer appears to be associated with a sex ratio skewed in favor of males and an increased risk of MZT. The clinicians should provide this information to their infe...Continue Reading

Citations

Sep 5, 2009·Journal of Assisted Reproduction and Genetics·Martha Agnes HentemannKjell Bertheussen
Aug 12, 2010·Journal of Assisted Reproduction and Genetics·Gabriela TauwinklovaVladimira Vranova
Aug 8, 2009·Human Reproduction·W VerpoestI Liebaers
May 18, 2010·Human Reproduction·M WiklandU B Wennerholm
Dec 13, 2012·Human Reproduction·S MäkinenT Tuuri
May 27, 2010·Molecular Human Reproduction·David K GardnerGeorge A Thouas
Jun 25, 2014·Reproductive Biology and Endocrinology : RB&E·Juan J TarínAntonio Cano
Jun 17, 2014·Seminars in Fetal & Neonatal Medicine·Georgina M Chambers, William Ledger
Jun 8, 2011·Human Genetics·I M van den BergJ H van Doorninck
Nov 29, 2014·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Thérèse H GriersmithSusan P Walker
Sep 24, 2015·Human Fertility : Journal of the British Fertility Society·Stephen HarbottleUNKNOWN Association Of Clinical Embryologists & The (ACE) British Fertility Society (BFS)
Feb 19, 2016·Systems Biology in Reproductive Medicine·Qiao-hua HeShi-hong Cui
Dec 18, 2015·Reproductive Biomedicine Online·Abha MaheshwariSiladitya Bhattacharya
Jan 9, 2016·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Fabio ParazziniEdgardo Somigliana
Dec 23, 2015·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Veronica SaraisEdgardo Somigliana
Mar 8, 2014·Fertility and Sterility·Walid E MaaloufIan C W Hardy
Nov 14, 2015·Journal of Assisted Reproduction and Genetics·Sotirios H SaravelosZi-Jiang Chen
May 30, 2013·Fertility and Sterility·UNKNOWN Practice Committees of the American Society for Reproductive Medicine and the Society for Assisted Reproductive Technology
Aug 9, 2012·Reproductive Biomedicine Online·Delphine DelrieuIsaac-Jacques Kadoch
Dec 27, 2011·Fertility and Sterility·UNKNOWN Practice Committee of Society for Assisted Reproductive Technology, UNKNOWN Practice Committee of American Society for Reproductive Medicine
Dec 14, 2011·Gynécologie, obstétrique & fertilité·L MartinF Guérif
Dec 25, 2015·Taiwanese Journal of Obstetrics & Gynecology·Valentina SotiroskaLars Johansson
Aug 7, 2010·Fertility and Sterility·Jennifer L EatonAlan S Penzias
May 15, 2010·Taiwanese Journal of Obstetrics & Gynecology·Pin-Yao LinKuo-Chung Lan
Feb 9, 2010·Fertility and Sterility·Bengt KällénPetra Otterblad Olausson
May 15, 2010·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Petra J G ZwijnenburgDorret I Boomsma
Oct 3, 2014·Journal of Cancer Survivorship : Research and Practice·Ainhoa GarcíaPeter Chan
Aug 26, 2015·Journal of Assisted Reproduction and Genetics·Efrat Esh-BroderTogas Tulandi
May 23, 2012·Human Fertility : Journal of the British Fertility Society·N R VulliemozJ Kurinczuk
Jan 17, 2012·Fertility and Sterility·Paul DevroeyUNKNOWN Menopur in GnRH Antagonist Cycles with Single Embryo Transfer Trial Group
Dec 10, 2014·Fertility and Sterility·Fernando BronetMarcos Meseguer
Jul 5, 2011·Fertility and Sterility·Ramazan MercanBulent Urman
Dec 6, 2014·Frontiers in Immunology·John P NewnhamJeffrey A Keelan

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