Impact of body mass index on the efficacy of endocrine therapy in patients with metastatic breast cancer - A retrospective two-center cohort study

The Breast : Official Journal of the European Society of Mastology
Luwam ZewenghielAntonis Valachis

Abstract

The aim of this study was to investigate the impact of body mass index (BMI) on the efficacy of endocrine therapy in postmenopausal women with metastatic hormone receptor breast cancer (HR+BC) as well as to identify if the potential difference in efficacy was associated with Fulvestrant only or both aromatase inhibitors (AIs) and Fulvestrant. A consecutive cohort of postmenopausal women with HR+metastatic breast cancer that have received endocrine therapy including Fulvestrant as a metastatic treatment strategy at the Departments of Oncology in Eskilstuna and Uppsala, Sweden, between 2008 and 2016 were identified. The primary outcome of the study was time to disease progression (TTP) during the treatment with Fulvestrant in overweight and obese women compared to patient with normal BMI. In total, 173 patients were enrolled in the study cohort, amongst these, 141 patients received both Fulvestrant and AIs and 32 received only Fulvestrant. No statistical significant association was observed between the three BMI categories and TTP, during Fulvestrant treatment (p = 0.136). The rates of objective response and clinical benefit due to Fulvestrant were similar among patients with normal weight, overweight and obesity, respectively. N...Continue Reading

Citations

Sep 19, 2019·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Matteo SantoniNicola Battelli
Dec 28, 2019·Journal of Clinical Laboratory Analysis·Yuanchun FengChenghua Luo
Mar 10, 2020·World Journal of Clinical Cases·Ying-Jie HaoYing-Li Li
Aug 5, 2020·Journal of the National Cancer Institute·Maria Alice FranzoiEvandro de Azambuja
Mar 10, 2019·The Journal of Steroid Biochemistry and Molecular Biology·Priya BhardwajKristy A Brown
Aug 6, 2021·Frontiers in Oncology·Chongru ZhaoYiping Wu
Sep 25, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Ines BaroneSebastiano Andò
Jan 11, 2022·Breast Cancer Research and Treatment·Rima PatelAmy Tiersten

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