Impact of Body Temperature Abnormalities on the Implementation of Sepsis Bundles and Outcomes in Patients With Severe Sepsis: A Retrospective Sub-Analysis of the Focused Outcome Research on Emergency Care for Acute Respiratory Distress Syndrome, Sepsis and Trauma Study

Critical Care Medicine
Shigeki KushimotoJAAM Focused Outcome Research on Emergency Care for Acute respiratory distress syndrome, Sepsis and Trauma (FORECAST) Group

Abstract

To investigate the impact of body temperature on disease severity, implementation of sepsis bundles, and outcomes in severe sepsis patients. Retrospective sub-analysis. Fifty-nine ICUs in Japan, from January 2016 to March 2017. Adult patients with severe sepsis based on Sepsis-2 were enrolled and divided into three categories (body temperature < 36°C, 36-38°C, > 38°C), using the core body temperature at ICU admission. None. Compliance with the bundles proposed in the Surviving Sepsis Campaign Guidelines 2012, in-hospital mortality, disposition after discharge, and the number of ICU and ventilator-free days were evaluated. Of 1,143 enrolled patients, 127, 565, and 451 were categorized as having body temperature less than 36°C, 36-38°C, and greater than 38°C, respectively. Hypothermia-body temperature less than 36°C-was observed in 11.1% of patients. Patients with hypothermia were significantly older than those with a body temperature of 36-38°C or greater than 38°C and had a lower body mass index and higher prevalence of septic shock than those with body temperature greater than 38°C. Acute Physiology and Chronic Health Evaluation II and Sequential Organ Failure Assessment scores on the day of enrollment were also significantly ...Continue Reading

References

Jun 1, 1992·Critical Care Medicine·R C BoneW J Sibbald
Apr 12, 2003·Critical Care Medicine·Mitchell M LevyUNKNOWN SCCM/ESICM/ACCP/ATS/SIS
May 6, 2004·Intensive Care Medicine·Daliana Peres BotaJean Louis Vincent
May 8, 2007·Journal of the American College of Surgeons·Brian R SwensonRobert G Sawyer
Jun 26, 2009·Critical Care Medicine·Kevin B Laupland
Sep 30, 2010·BMC Geriatrics·Ravindranath TiruvoipatiJohn Botha
Sep 20, 2011·Critical Care Medicine·Kevin B LauplandJean-François Timsit
Feb 1, 2012·Intensive Care Medicine·Paul Jeffrey YoungKathryn Rowan
Jan 29, 2013·Critical Care Medicine·R Phillip DellingerUNKNOWN Surviving Sepsis Campaign Guidelines Committee including the Pediatric Subgroup
Nov 14, 2013·Critical Care : the Official Journal of the Critical Care Forum·Shigeki KushimotoUNKNOWN JAAM Sepsis Registry Study Group
Feb 18, 2014·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Hiroshi OguraUNKNOWN Japanese Association for Acute Medicine Sepsis Registry (JAAMSR) Study Group
Feb 24, 2016·JAMA : the Journal of the American Medical Association·Mervyn SingerDerek C Angus
Apr 21, 2018·Intensive Care Medicine·Mitchell M LevyAndrew Rhodes
Nov 24, 2018·Critical Care : the Official Journal of the Critical Care Forum·Toshikazu AbeUNKNOWN JAAM FORECAST group

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Citations

Jul 22, 2020·The Journal of Infectious Diseases·Jeremy WeinbergerMichael Klompas
Jul 2, 2020·Critical Care : the Official Journal of the Critical Care Forum·Takashi ShimazuiUNKNOWN JAAM FORECAST Group
May 7, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Chanu RheeMichael Klompas
Nov 25, 2020·Surgical Infections·Christopher A GuidryRobert D Winfield
Feb 8, 2021·Resuscitation·Jesper JohnssonNiklas Nielsen
May 25, 2020·The Journal of Pediatrics·Sriram RamgopalRobert W Hickey

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