Abstract
Dysfunctional gut microbiota is a common finding in patients with metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM). Recent clinical trials have assessed whether botanical fermented foods (BFFs) have beneficial effects on metabolic biomarkers, inflammatory markers and gut microbiota. The aim of this review is to critically evaluate all randomised controlled trials (RCTs) of BFF for evidence of impact on the outcome measures of these disease states. Four electronic databases (Embase, MEDLINE, CENTRAL and Google Scholar) as well as the grey literature will be searched from inception to present without language or publication status restrictions applied. Eligible RCTs which have enrolled adult participants with T2DM, any MetS components or combinations of these components, treated prophylactically or therapeutically with any botanical fermented food intervention, compared with a control group (no intervention, placebo or active control) will be assessed. Primary outcomes are related to the target conditions, including metabolic biomarkers, inflammatory markers and gut microbiota composition/function. Using Covidence, two independent investigators will conduct title and abstract screening, followed by full-text screenin...Continue Reading
References
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Apr 26, 2008·BMJ : British Medical Journal·Gordon H GuyattUNKNOWN GRADE Working Group
Mar 20, 2012·Cell·Jose C ClementeRob Knight
May 23, 2012·Journal of Pathology Informatics·George ToouliJohanna Westbrook
Oct 2, 2012·Nature·Junjie QinJun Wang
Jun 19, 2013·Best Practice & Research. Clinical Gastroenterology·Amandine Everard, Patrice D Cani
Dec 18, 2013·Nature·Lawrence A DavidPeter J Turnbaugh
Jan 16, 2014·Journal of Physiological Anthropology·Eva M SelhubAlison C Bested
Nov 20, 2014·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·S O'Neill, L O'Driscoll
Jan 3, 2015·Systematic Reviews·David MoherUNKNOWN PRISMA-P Group
May 11, 2016·Systematic Reviews·Lars JørgensenAsbjørn Hróbjartsson
Dec 22, 2016·Current Opinion in Biotechnology·Maria L MarcoRobert Hutkins
Sep 13, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·R C BortolinJ C F Moreira
Apr 5, 2018·Nutrients·Doreen GilleGuy Vergères