Abstract
BRAF mutations are divided into functional classes distinguished by signaling mechanism and kinase activity: V600-mutant kinase-activating monomers (class I), kinase-activating dimers (class II), and kinase-inactivating heterodimers (class III). The relationship between functional class and disease characteristics in BRAF-mutant non-small cell lung cancer (NSCLC) has not been fully explored. We performed a retrospective analysis of BRAF-mutant NSCLCs treated at 2 institutions from 2005 to 2017 to determine clinicopathologic characteristics, progression-free survival (PFS) on chemotherapy, and overall survival (OS). We identified 236 patients with BRAF-mutant NSCLC (n = 107 class I, n = 75 class II, and n = 54 class III). Patients with class II or III mutations were more likely to have brain metastases (P ≤ 0.01) and RAS coalterations (P ≤ 0.001) than class I. Compared with class I, PFS on chemotherapy was shorter for class II (P = 0.069) and class III (P = 0.034). OS was shorter for class II and III (class I, 40.1 months; class II, 13.9 months; and class III, 15.6 months; I vs. II, P < 0.001; I vs. III, P = 0.023); however, this difference was driven by fewer extrathoracic metastases and higher use of targeted therapies in clas...Continue Reading
References
Apr 13, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul K PaikGregory J Riely
Aug 10, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Antonio MarchettiFiamma Buttitta
Jul 9, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stephanie CardarellaPasi A Jänne
Sep 17, 2013·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Oliver GautschiJoachim Diebold
May 23, 2014·JAMA : the Journal of the American Medical Association·Mark G KrisPaul A Bunn
Oct 3, 2014·Cancer·Liza C VillaruzMark G Kris
Nov 11, 2014·Nature Medicine·Zongli ZhengLong Phi Le
Dec 2, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Anya M LitvakGregory J Riely
Jun 9, 2015·The Lancet Oncology·James C-H YangYi-Long Wu
Jul 23, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Oliver GautschiJulien Mazières
Sep 8, 2015·Cancer Cell·Zhan YaoNeal Rosen
Oct 27, 2015·BMC Cancer·Gang ZhengMing-Tseh Lin
Jan 19, 2016·Lancet·Fabrice BarlesiUNKNOWN Biomarkers France contributors
Jun 11, 2016·The Lancet Oncology·David PlanchardBruce E Johnson
Nov 3, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S-H LeeK Park
Nov 25, 2016·JCI Insight·Lynette M ShollLaura E MacConaill
Dec 3, 2016·Cancer·Dae Won KimMichael A Davies
Mar 25, 2017·Cancer Discovery·Emmet J JordanGregory J Riely
May 10, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeremy C JonesAxel Grothey
May 11, 2017·The Oncologist·Christina S BaikHeather A Wakelee
May 12, 2017·JAMA : the Journal of the American Medical Association·Pasi A JänneJohan Vansteenkiste
Aug 8, 2017·Nature·Zhan YaoNeal Rosen
Sep 19, 2017·The Lancet Oncology·David PlanchardBruce E Johnson
Sep 28, 2017·Oncotarget·Amir NoeparastJacques De Grève
Jan 18, 2018·Cell·Chiara AmbrogioPasi A Jänne
Jan 20, 2018·Oncogene·Hiroshi KotaniHiromichi Ebi
Feb 9, 2018·Nature·David M HymanDavid B Solit
Jun 16, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Matthew DanknerApril A N Rose
Nov 1, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C LeducUNKNOWN French Cooperative Thoracic Intergroup (IFCT)
Citations
Jul 7, 2019·BMC Cancer·Parvez M LokhandwalaMing-Tseh Lin
Oct 4, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christian MenzerJessica C Hassel
Sep 1, 2019·Journal of Translational Medicine·Quan LinHong Zhu
Sep 20, 2019·Cancers·Jillian Wilhelmina Paulina BrachtRafael Rosell
Aug 26, 2020·Cell Biology International·Xiujuan ShiJue Li
Apr 17, 2020·Current Oncology Reports·Alessandro RussoChristian Rolfo
Apr 23, 2020·Journal of Nanobiotechnology·Congli TangNongyue He
May 17, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Matthew Dankner, April A N Rose
Dec 15, 2020·Critical Reviews in Oncology/hematology·Evgeny N ImyanitovEvgeny V Levchenko
Sep 9, 2020·Clinical Lung Cancer·Nuria ChicBenjamin Besse
Jan 29, 2021·JAMA Network Open·Yiqing ZhaoGang Zheng
Jan 1, 2021·OncoTargets and Therapy·Xuejun WangWeijun Zhang
Jan 14, 2021·International Journal of Molecular Sciences·Sara S FoisGiuseppe Palmieri
Jan 22, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J MazieresJ Y Blay
Mar 6, 2021·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Anna-Lena VolckmarAlbrecht Stenzinger
Mar 7, 2021·Cancers·David KönigSacha I Rothschild
Jun 3, 2020·Critical Reviews in Oncology/hematology·Daniele FrisoneAlfredo Addeo
Mar 17, 2021·Critical Reviews in Oncology/hematology·Alessandro De TomaMarina Chiara Garassino
Mar 24, 2021·Nature Communications·Joshua H CookKevin M Haigis
Oct 11, 2020·Critical Reviews in Oncology/hematology·Umberto MalapelleGiancarlo Troncone
Apr 8, 2020·Clinical Lung Cancer·Amélie BourhisArnaud Uguen
Apr 20, 2021·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Marcel WieswegMartin Schuler
Sep 29, 2020·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Ibiayi Dagogo-Jack
Jun 17, 2020·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Marcelo V NegraoCaroline E McCoach